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Effect of Nitric Oxide via Cardiopulmonary Bypass on Ventilator-Free Days in Young Children Undergoing Congenital Heart Disease Surgery

2022; American Medical Association; Volume: 328; Issue: 1 Linguagem: Inglês

10.1001/jama.2022.9376

1538-3598

Luregn J. Schlapbach, Kristen Gibbons, Stephen Horton, Kerry Johnson, Debbie Long, David Buckley, Simon Erickson, Marino Festa, Yves d’Udekem, Nelson Alphonso, David S. Winlaw, Carmel Delzoppo, Kim van Loon, Mark Jones, Paul J. Young, Warwick Butt, Andreas Schibler, Johnny Millar, Kate Masterson, John Beca, Taryn Evans, Shelley Coetzer, Claire Sherring, Jennifer Darvas, Killian O’Shaughnessy, Chong Tien Goh, Gail Harper, Sam Barr, Rae Kelly, Hannah Thomson, Kelly A. Holmes, Nigel Slade, David Andrews, Carla Zazulak, Benjamin O. Anderson, Antje Blumenthal, Jonas Fooken, Endrias Ergetu, Brenda Gannon, Renate Le Marsney, Trang Pham, Annelies Hennink, Erik Koomen, Nicole J.C.W. van Belle-van Haaren, Bram van Wijk,

Mechanical Circulatory Support Devices

In children undergoing heart surgery, nitric oxide administered into the gas flow of the cardiopulmonary bypass oxygenator may reduce postoperative low cardiac output syndrome, leading to improved recovery and shorter duration of respiratory support. It remains uncertain whether nitric oxide administered into the cardiopulmonary bypass oxygenator improves ventilator-free days (days alive and free from mechanical ventilation).