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Endothelial biomarkers as predictors for haemodialysis need in severe leptospirosis patients (Weil's disease)
2022; Wiley; Volume: 27; Issue: 8 Linguagem: Inglês
10.1111/tmi.13796
ISSN1365-3156
AutoresGdayllon Cavalcante Meneses, Pedro Eduardo Andrade de Carvalho Gomes, Gabriela Studart Galdino, Gabriela Freire Bezerra, Ranieri Sales de Souza Santos, Alice Maria Costa Martins, Geraldo Bezerra da Silva, Alexandre Braga Libório, Roberto da Justa Pires Neto, Elizabeth De Francesco Daher,
Tópico(s)Venous Thromboembolism Diagnosis and Management
ResumoTropical Medicine & International HealthVolume 27, Issue 8 p. 727-734 RESEARCH ARTICLE Endothelial biomarkers as predictors for haemodialysis need in severe leptospirosis patients (Weil's disease) Gdayllon Cavalcante Meneses, Corresponding Author Gdayllon Cavalcante Meneses gdayllon@yahoo.com.br Medical Sciences Post-Graduate Program, Federal University of Ceará, Fortaleza, Brazil Correspondence Gdayllon Cavalcante Meneses, School of Medicine, Federal University of Ceara, Rua Aluisio Azevedo 374, Fortaleza, Ceará 60510-072, Brazil. Email: gdayllon@yahoo.com.brSearch for more papers by this authorPedro Eduardo Andrade de Carvalho Gomes, Pedro Eduardo Andrade de Carvalho Gomes Medical Sciences Post-Graduate Program, Federal University of Ceará, Fortaleza, BrazilSearch for more papers by this authorGabriela Studart Galdino, Gabriela Studart Galdino Medical Sciences Post-Graduate Program, Federal University of Ceará, Fortaleza, BrazilSearch for more papers by this authorGabriela Freire Bezerra, Gabriela Freire Bezerra Pharmacology Post-Graduate Program, Federal University of Ceará, Fortaleza, BrazilSearch for more papers by this authorRanieri Sales de Souza Santos, Ranieri Sales de Souza Santos Pharmacology Post-Graduate Program, Federal University of Ceará, Fortaleza, BrazilSearch for more papers by this authorAlice Maria Costa Martins, Alice Maria Costa Martins Pharmacology Post-Graduate Program, Federal University of Ceará, Fortaleza, BrazilSearch for more papers by this authorGeraldo Bezerra da Silva Junior, Geraldo Bezerra da Silva Junior Public Health and Medical Sciences Graduate Programs, University of Fortaleza, Fortaleza, BrazilSearch for more papers by this authorAlexandre Braga Libório, Alexandre Braga Libório Post-Graduate Program, University of Fortaleza, Fortaleza, BrazilSearch for more papers by this authorRoberto da Justa Pires Neto, Roberto da Justa Pires Neto Public Health Post-Graduate Program, Department of Community Health, School of Medicine, Federal University of Ceara, Fortaleza, Brazil Sao Jose Hospital of Infectious Diseases, Fortaleza, BrazilSearch for more papers by this authorElizabeth De Francesco Daher, Elizabeth De Francesco Daher Medical Sciences Post-Graduate Program, Federal University of Ceará, Fortaleza, BrazilSearch for more papers by this author Gdayllon Cavalcante Meneses, Corresponding Author Gdayllon Cavalcante Meneses gdayllon@yahoo.com.br Medical Sciences Post-Graduate Program, Federal University of Ceará, Fortaleza, Brazil Correspondence Gdayllon Cavalcante Meneses, School of Medicine, Federal University of Ceara, Rua Aluisio Azevedo 374, Fortaleza, Ceará 60510-072, Brazil. Email: gdayllon@yahoo.com.brSearch for more papers by this authorPedro Eduardo Andrade de Carvalho Gomes, Pedro Eduardo Andrade de Carvalho Gomes Medical Sciences Post-Graduate Program, Federal University of Ceará, Fortaleza, BrazilSearch for more papers by this authorGabriela Studart Galdino, Gabriela Studart Galdino Medical Sciences Post-Graduate Program, Federal University of Ceará, Fortaleza, BrazilSearch for more papers by this authorGabriela Freire Bezerra, Gabriela Freire Bezerra Pharmacology Post-Graduate Program, Federal University of Ceará, Fortaleza, BrazilSearch for more papers by this authorRanieri Sales de Souza Santos, Ranieri Sales de Souza Santos Pharmacology Post-Graduate Program, Federal University of Ceará, Fortaleza, BrazilSearch for more papers by this authorAlice Maria Costa Martins, Alice Maria Costa Martins Pharmacology Post-Graduate Program, Federal University of Ceará, Fortaleza, BrazilSearch for more papers by this authorGeraldo Bezerra da Silva Junior, Geraldo Bezerra da Silva Junior Public Health and Medical Sciences Graduate Programs, University of Fortaleza, Fortaleza, BrazilSearch for more papers by this authorAlexandre Braga Libório, Alexandre Braga Libório Post-Graduate Program, University of Fortaleza, Fortaleza, BrazilSearch for more papers by this authorRoberto da Justa Pires Neto, Roberto da Justa Pires Neto Public Health Post-Graduate Program, Department of Community Health, School of Medicine, Federal University of Ceara, Fortaleza, Brazil Sao Jose Hospital of Infectious Diseases, Fortaleza, BrazilSearch for more papers by this authorElizabeth De Francesco Daher, Elizabeth De Francesco Daher Medical Sciences Post-Graduate Program, Federal University of Ceará, Fortaleza, BrazilSearch for more papers by this author First published: 27 June 2022 https://doi.org/10.1111/tmi.13796 Sustainable Development Goal: Good Health and Wellbeing. Funding information: The National Council for Scientific and Technological Development, Grant/Award Numbers: 301174/2017-2, 405963/2016-5; Brazilian Coordination of Post-Graduation—Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Grant/Award Number: 88882.306447/2018-01 Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Objective To investigate the prediction ability of vascular injury biomarkers for haemodialysis requirement in patients with severe leptospirosis. Methods Prospective study with severe leptospirosis patients hospitalised in Fortaleza, Brazil. Blood samples were collected hospital admission to quantify vascular injury biomarkers: syndecan-1, ICAM-1, VCAM-1, angiopoietin-2 and FGF-23. Two groups were evaluated according to haemodialysis requirement during hospital stay. Results Twenty-seven patients were included, with a mean age of 39 ± 18 years. 88.9% were males. 53.8% needed haemodialysis and presented higher levels on hospital admission of syndecan-1 (572 [300–811] vs. 263 [106–421] ng/ml; p = 0.03), angiopoietin-2 (1.52 [0.72–2.72] vs. 0.63 [0.4–1.38] ng/ml; p = 0.01), and FGF-23 (291 [56–2031] vs. 10 [10–806] pg/ml; p = 0.021). Syndecan-1 showed significant correlation with creatinine (r = 0.546; p = 0.05) and total bilirubin levels (r = 0.534; p = 0.013) on hospital admission. Angiopoietin-2 showed significant correlation with creatinine levels (r = 0.513; p = 0.009) on hospital admission and with number of haemodialysis sessions (r = 0.406; p = 0.049). No significant correlation was found with FGF-23. Regarding prognostic performance, combined syndecan-1 and angiopoietin-2 levels had a better ability to predict haemodialysis need in patients with severe leptospirosis (AUC-ROC = 0.744 [95% CI: 0.545–0.943] p = 0.035). Conclusion Syndecan-1 and angiopoietin-2 were associated with haemodialysis need in patients with severe leptospirosis and may be useful to improve therapeutic approach and reduce mortality. Volume27, Issue8August 2022Pages 727-734 RelatedInformation
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