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Adolescent development of multiscale structural wiring and functional interactions in the human connectome

2022; National Academy of Sciences; Volume: 119; Issue: 27 Linguagem: Inglês

10.1073/pnas.2116673119

1091-6490

Bo‐yong Park, Casey Paquola, Richard A. I. Bethlehem, Oualid Benkarim, Bratislav Mišić, Jonathan Smallwood, Edward T. Bullmore, Boris C. Bernhardt, Edward T. Bullmore, Raymond J. Dolan, Ian Goodyer, Peter Fonagy, Peter B. Jones, Michael Moutoussis, Tobias U. Hauser, Sharon Neufeld, Rafael Romero-García, Michelle St Clair, Petra E. Vértes, Kirstie Whitaker, Becky Inkster, Gita Prabhu, Cinly Ooi, Umar Toseeb, Barry Widmer, Junaid Bhatti, Laura Villis, Ayesha Alrumaithi, Sarah Birt, Aislinn Bowler, Kalia Cleridou, Hina Dadabhoy, Emma Jane Davies, Ashlyn Firkins, Sian Granville, Elizabeth Harding, Alexandra Hopkins, Daniel Isaacs, Janchai King, Danae Kokorikou, Christina Maurice, Cleo McIntosh, Jessica Memarzia, Harriet Mills, Ciara O’Donnell, Sara Pantaleone, Jenny Scott, Beatrice Kiddle, Ela Polek, Pasco Fearon, John Suckling, Anne‐Laura van Harmelen, Rogier Kievit, Sam Chamberlain,

Advanced MRI Techniques and Applications

Adolescence is a time of profound changes in the physical wiring and function of the brain. Here, we analyzed structural and functional brain network development in an accelerated longitudinal cohort spanning 14 to 25 y ( n = 199). Core to our work was an advanced in vivo model of cortical wiring incorporating MRI features of corticocortical proximity, microstructural similarity, and white matter tractography. Longitudinal analyses assessing age-related changes in cortical wiring identified a continued differentiation of multiple corticocortical structural networks in youth. We then assessed structure–function coupling using resting-state functional MRI measures in the same participants both via cross-sectional analysis at baseline and by studying longitudinal change between baseline and follow-up scans. At baseline, regions with more similar structural wiring were more likely to be functionally coupled. Moreover, correlating longitudinal structural wiring changes with longitudinal functional connectivity reconfigurations, we found that increased structural differentiation, particularly between sensory/unimodal and default mode networks, was reflected by reduced functional interactions. These findings provide insights into adolescent development of human brain structure and function, illustrating how structural wiring interacts with the maturation of macroscale functional hierarchies.