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Prediction of peritoneal soiling in acute appendicitis with simple clinical and laboratory data. Prospective, multicenter, cohort study of 2,645 adult patients nationwide

2022; Wolters Kluwer; Volume: 104; Linguagem: Inglês

10.1016/j.ijsu.2022.106741

1743-9191

Núria Lluís, J. Parra, C. Villodre, Pedro Zapater, Amirhossein Jalali, M. Cantó, Luís Mena, José Manuel Ramia, Fèlix Lluı́s, Nuno Afonso, V. Aguilella, Javier Aguiló, Juan Carlos Alados, M. Alberich, Ana Belén Apio, R. Balongo, E. Bra, Alberto Bravo-Gutiérrez, F.J. Briceño, J. Cabañas, Gloria Cánovas, I. Caravaca, Silvia Carbonell Morote, E. Carrera-Dacosta, E. Castro E, Cèlia Caula, E. Choolani-Bhojwani, Antonio Daponte, S. Corral, C. Cuenca, Yuhamy Curbelo, M. M. Delgado-Morales, Luciano Delgado-Plasencia, E. Doménech, Ana Estévez, Alfredo Feria, M. A. Gascón-Domínguez, Rajesh Gianchandani Moorjani, C. González, M. A. González, R. Hevia, José Manuel Hidalgo, Miguel J. A. Láinez, Francisca López, José López‐Fernández, José Antonio López-Ruiz, P Lora-Cumplido, Zoilo Madrazo González, Joaquín Marchena Gómez, B. Marenco de la Cuadra, Shanique Martin, Isidro Martínez Casas, Pablo Pérez‐Martínez, A. Mena-Mateos, Dieter Morales-García, Claudia Mulas, E. Muñoz-Forner, Antonio Naranjo, Antonio Navarro‐Sánchez, Isabel Oliver, Irene Ortega, R. Ortega-Higueruelo, S. Ortega-Ruiz, Javier Osorio, M. H. Padín, José Pamies, María Celeste Gonzales Paredes, Felipe Pareja‐Ciuro, Carmen Victoria Pérez-Guarinos, B. Pérez-Saborido, José Pintor‐Tortolero, K.T. Plua-Muniz, M. Rey, Ingrid Rodrı́guez, Cristina Ballesteros Ruiz, R Caiña Ruiz, Sheila Picorelli Ruiz, Antonio Sánchez-Porto, David Sánchez‐Infantes, Rosa María Sánchez Pérez, F. Sánchez-Cabezudo, Raquel Sánchez‐Santos, Julio Pascual Santos, Pilar Serrano, Víctor Soria‐Aledo, L. Taccogna, Luis Tallón‐Aguilar, J. H. Valdivia-Risco, H. Vallverdú-Cartié, Carlos Federico Varela, Jesús Villar, Natalia Zambudio,

Intraperitoneal and Appendiceal Malignancies

In order to facilitate the preoperative prediction of complicated appendicitis, we propose a complementary approach by selecting an endpoint defined by the intraoperative finding of peritoneal soiling (PS). Over a 6-month period, 38 centers (5% of all public hospitals) attending emergency general surgery patients on a 24-h, 7-days a week basis, enrolled consecutive adult patients requiring appendectomy. Patients were stratified according to the absence or the finding of PS during the surgical procedure. A total of 2645 patients were included; median age (IQR) was 35 (22–51) years, 44.3% were female. The laparoscopic approach was used in 70.8% of appendectomies. In a third of patients (31.7%), there was PS with pus around the appendix, or bowel contents, free pus, or blood in the peritoneal cavity. To develop the prediction model, 1764 patients were randomly selected for the derivation cohort and the remaining 881 patients were assigned to the validation cohort. On multivariable logistic regression analysis of all patients, two clinical variables (age, and pulse) and three laboratory variables (serum urea, serum sodium, and white blood cell count) were individually associated (P < .05) with a greater probability of having PS (Hosmer-Lemeshow chi, 1.63; P = .99; C-statistic, 0.7). Based on the multivariable regression model, both static and dynamic nomograms were developed for the prediction of PS in patients with acute appendicitis. The entry of simple clinical and laboratory variables in the dynamic nomogram may be useful in guiding the initial management of patients with acute appendicitis in resource-limited settings.