Produção Nacional
Revisado por pares
Exploiting mesoporous silica, silver and gold nanoparticles for neurodegenerative diseases treatment
2022; Elsevier BV; Volume: 624; Linguagem: Inglês
10.1016/j.ijpharm.2022.121978
ISSN1873-3476
AutoresTaís de Cássia Ribeiro, Rafael Miguel Sábio, Gabriela Corrêa Carvalho, Bruno Fonseca‐Santos, Marlus Chorilli,
Tópico(s)Advanced Nanomaterials in Catalysis
ResumoNeurodegenerative diseases (NDs) are considered public health problem characterized by neural loss causing cognitive and behavioral impairments. It is currently possible to use drugs capable of controlling the symptoms caused by these diseases. However, treatment is not able to prevent neural loss. In addition, poor solubility, low bioavailability due to the inability for crossing the blood–brain barrier (BBB) are described as the main limitations of the treatment. Nanotechnology involves the development of nanoscale drug delivery systems and they have been employed to optimize therapeutics face to several diseases treatment. In light of this, this review describes the highlights on the fabrication of nanotechnology-based drug delivery systems emphasizing mesoporous silica, gold and silver nanoparticles (MSNs, AuNPs and AgNPs, respectively) and their biological behavior for the treatment of Alzheimer's and Parkinson diseases (ADs and PDs, respectively).
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