Alcoholic foamy degeneration: a unique variant of ALD that shows a characteristic pattern of gene expression with upregulation of lipid metabolism and mitochondrial genes and downregulation of fibrosis genes
2022; Elsevier BV; Volume: 77; Linguagem: Inglês
10.1016/s0168-8278(22)00659-6
ISSN1600-0641
AutoresJordi Gratacós‐Ginès, Delia Blaya, Helena Hernandéz Evole, Carla Montironi, Emma Avitabile, Martina Pérez, Marta Cervera, Marta Carol, Ana Belén Rubio, Núria Fabrellas, Anna Soria, Octavi Bassegoda, Laura Napoleone, Ann T., Adrià Juanola, Isabel Graupera, Alba Díaz, Juan José Lozano, Pere Ginés, Elisa Pose,
Tópico(s)Neurological diseases and metabolism
Resumonegative predictive is 89.7%.Grad-CAM highlighted distinct regions within each patch that the algorithm used to make its decisions.Figure: (a) Receiver operating characteristic (ROC) curve for the CNN's classification of ASH versus NASH.(b) Confusion matrix for the CNN; a diagnosis of ASH is indicated by "Positive" and a diagnosis of NASH is indicated by "Negative."(c) Activation map for classification of ASH patch (top row) and NASH patch (bottom row).Conclusion: Our deep learning-based AI algorithm had an outstanding performance for patch-level classification of liver biopsy images from patients with ASH and NASH.After further validation on a larger set of liver biopsy images and evaluation of model performance at the level of whole slides, our AI algorithm may prove to be a novel way to distinguish ASH versus NASH histologically.
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