The uptake of extracellular lipids promotes cholangiocarcinoma progression
2022; Elsevier BV; Volume: 77; Linguagem: Inglês
10.1016/s0168-8278(22)01611-7
ISSN1600-0641
AutoresMikel Ruiz de Gauna, Francesca Biancaniello, Francisco González‐Romero, Pedro M. Rodrigues, Ainhoa Lapitz, Beatriz Gómez Santos, Paula Olaizola, Sabina Di Matteo, Igor Aurrekoetxea, Ibone Labiano, Ane Nieva‐Zuluaga, Asier Benito‐Vicente, María J. Perugorria, Maider Apodaka‐Biguri, Nuno Paiva, Diego Sáenz de Urturi, Xabier Buqué, Igotz Delgado, Cesar Augusto Martín, Mikel Azkargorta, Félix Elortza, Diego F. Calvisi, Jesper N. Andersen, Domenico Alvaro, Vincenzo Cardinale, Luís Bujanda, Jesús M. Bañales, Patricia Aspichueta,
Tópico(s)RNA modifications and cancer
Resumoprogression free survival (PFS) (>1 year) after liver resection (Fig1 C).PCR results showed high expression of OPN in HCC tumour tissue (Fig1 D) and there was a positive correlation between OPN with the ligands of CTLA-4 (CD80/CD86) and TIM-3 (LGALS9) (Fig1 E).Plasma PD-L1 and CCL-17 levels in untreated HCC (n = 48) were both higher when compared to other HCC treated groups (n = 25; n = 19) and positively correlated with OPN.Furthermore, immunofluorescent staining showed that the expression of both OPN and PD-L1 were upregulated in tumour, with high signal of OPN around tumour vasculature.While CD8 was downregulated in tumour and paired adjacent tumour tissue.Conclusion: OPN has been shown as a potential marker for both diagnosis and prognosis in HCC.The positive correlations between OPN, PD-L1 and chemokine of T-regulatory cells CCL-17 in plasma, suggest that high OPN levels is associated with a weakened antitumour immunity.This indication was further confirmed by PCR results and immunofluorescent staining.
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