One-pot, three-component synthesis of novel coumarinyl-pyrazolo[3,4-b]pyridine-3-carboxylate derivatives using [AcMIm]FeCl4 as recyclable catalyst
2022; Elsevier BV; Volume: 1268; Linguagem: Inglês
10.1016/j.molstruc.2022.133623
ISSN1872-8014
AutoresSrinivasa Rao Ambati, Jeevan Lal Patel, Komal Chandrakar, Uttam Kumar Sarkar, Santhosh Penta, Subhash Banerjee, Rajender S. Varma,
Tópico(s)Synthesis and Biological Evaluation
ResumoMulticomponent synthesis of novel coumarin-based fused pyrazolo[3,4-b]pyridine-3-carboxylate derivatives was developed using acidic ionic liquid, 1-acyl-3-methylimidazolium tetrachloroferrate ([AcMIm]FeCl4), under mild and environmentally benign reaction conditions. [AcMIm]FeCl4 served as a catalyst as well as the reaction medium and was reused for at least four times without significant loss of yield. The ensuing compounds (4a-4p) were identified by FT-IR, 1H NMR and 13C NMR and mass spectroscopic studies. The developed method offers several advantages such as a simple protocol, excellent yields of the products (90–92%), shorter reaction time (2 h), recyclability of the catalyst, eco-friendly reaction conditions and better values of green chemistry metrics like low E factor (0.32), high reaction mass efficiency (75.28%), low process mass efficiency (1.32) and high atom economy (81.82).
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