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Males and females with first episode psychosis present distinct profiles of social cognition and metacognition

2022; Springer Science+Business Media; Volume: 272; Issue: 7 Linguagem: Inglês

10.1007/s00406-022-01438-0

1433-8491

Marta Ferrer-Quintero, Daniel Fernández, Raquel López-Carrilero, Irene Birulés, Ana Barajas, Ester Lorente-Rovira, Ana Luengo, Luciana Díaz-Cutraro, Marina Verdaguer, Helena García‐Mieres, Alfonso Gutiérrez‐Zotes, Eva Grasa, Esther Pousa, Elena Huerta‐Ramos, Trini Peláez, María Luisa Barrigón, Juana Gómez‐Benito, Fermín González-Higueras, Isabel Ruiz-Delgado, Jordi Cid, Steffen Moritz, Julia Sevilla‐Llewellyn‐Jones, Andrea Acevedo, J. Anglès, Meysam Argany, Ana Barajas, María Luisa Barrigón, M. Beltrán, Irene Birulés, J.L. Bogas, Ángel Cabezas, N. Camprubí, M. Carbonero, E. Carrasco, R. Casañas, Jordi Cid, E. Conesa, Iluminada Corripio, P. Cortes, Josep Crosas, Ana de Apraiz, Miguel Basauri-Delgado, Luis García Domínguez, Ma José Escartí, A. Escudero, I. Esteban Pinos, Carolina Franco, Celso Iglesias García, Victoria Villalta Gil, R. Gonzalez-Casares, Fermín González Higueras, M. L. González-Montoro, E. González, Eva Grasa, A Guasp, Alfonso Gutiérrez‐Zotes, Maria Elena Huerta‐Ramos, P. Huertas, A. Jiménez-Díaz, L. L. Lalucat, Blanca Llácer, Raquel López-Carrilero, Elena Lorente, Ana Luengo, N. Mantecón, Laia Mas-Expósito, M. Montes, Steffen Moritz, E. Murgui, M. Núñez, Susana Ochoa, E. Palomer, E. Paniego, Trini Peláez, Víctor Pérez, K. Planell, C. Planellas, P. Pleguezuelo-Garrote, Esther Pousa, Mireia Rabella, M. Renovell, R. Rubio, Isabel Ruiz-Delgado, M. San Emeterio, Stephany Sanchez, Julio Sanjuán, B. Sans, Lisa M. Schilling, H. Sió, M. Teixidó, Pilar Román Torres, M. A. Vila, Regina Vila-Badía, F. Villegas, Raúl Villellas, Susana Ochoa,

Mental Health and Psychiatry

Deficits in social cognition and metacognition impact the course of psychosis. Sex differences in social cognition and metacognition could explain heterogeneity in psychosis. 174 (58 females) patients with first-episode psychosis completed a clinical, neuropsychological, social cognitive, and metacognitive assessment. Subsequent latent profile analysis split by sex yielded two clusters common to both sexes (a Homogeneous group, 53% and 79.3%, and an Indecisive group, 18.3% and 8.6% of males and females, respectively), a specific male profile characterized by presenting jumping to conclusions (28.7%) and a specific female profile characterized by cognitive biases (12.1%). Males and females in the homogeneous profile seem to have a more benign course of illness. Males with jumping to conclusions had more clinical symptoms and more neuropsychological deficits. Females with cognitive biases were younger and had lower self-esteem. These results suggest that males and females may benefit from specific targeted treatment and highlights the need to consider sex when planning interventions.