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Transient rapamycin treatment during developmental stage extends lifespan in Mus musculus and Drosophila melanogaster

2022; Springer Nature; Volume: 23; Issue: 9 Linguagem: Inglês

10.15252/embr.202255299

1469-3178

Giuseppe Aiello, Cosimo Sabino, Davide Pernici, Matteo Audano, Francesco Antonica, Matteo Gianesello, Claudio Ballabio, Alessandro Quattrone, Nico Mitro, Alessandro Romanel, Alessia Soldano, Luca Tiberi,

Birth, Development, and Health

Lifespan is determined by complex and tangled mechanisms that are largely unknown. The early postnatal stage has been proposed to play a role in lifespan, but its contribution is still controversial. Here, we show that a short rapamycin treatment during early life can prolong lifespan in Mus musculus and Drosophila melanogaster. Notably, the same treatment at later time points has no effect on lifespan, suggesting that a specific time window is involved in lifespan regulation. We also find that sulfotransferases are upregulated during early rapamycin treatment both in newborn mice and in Drosophila larvae, and transient dST1 overexpression in Drosophila larvae extends lifespan. Our findings unveil a novel link between early-life treatments and long-term effects on lifespan.