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FLASH radiotherapy: an emerging approach in radiation therapy

2022; Elsevier BV; Volume: 27; Issue: 2 Linguagem: Inglês

10.5603/rpor.a2022.0038

2083-4640

Natalia Matuszak, Wiktoria Maria Suchorska, Piotr Milecki, Marta Kruszyna‐Mochalska, Agnieszka Misiarz, Jacek Pracz, Julian Malicki,

Radiation Detection and Scintillator Technologies

FLASH radiotherapy (RT) is a technique involving the delivery of ultra-high dose rate radiation to the target. FLASH-RT has been shown to reduce radiation-induced toxicity in healthy tissues without compromising the anti-cancer effects of treatment compared to conventional radiation therapy. In the present article, we review the published data on FLASH-RT and discuss the current state of knowledge of this novel approach. We also highlight the technological constraints and complexity of FLASH-RT and describe the physics underlying this modality, particularly how technology supports energy transfer by ionising radiation (e.g., beam on/off sequence, pulse-energy load, intervals). We emphasise that current preclinical experience is mostly based on FLASH electrons and that clinical application of FLASH-RT is very limited. The incorporation of FLASH-RT into routine clinical radiotherapy will require the development of devices capable of producing FLASH photon beams.