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2022; Elsevier BV; Volume: 113; Issue: 5 Linguagem: Inglês

10.1016/j.ijrobp.2022.05.007

1879-355X

Romaana Mir, Agata Rembielak,

Primary lymphoepithelioma-like carcinomas of the skin (LELCS) are rare, indolent tumors that develop in sun-exposed skin. LELCS are regarded as a variant of cutaneous squamous cell carcinoma with low metastatic risk. 1 McClelland S Mitin T A real pain in the neck. Int J Radiat Oncol Biol Phys. 2022; 113: 907-908 Abstract Full Text Full Text PDF PubMed Scopus (3) Google Scholar , 2 Oliveira CC Nóbrega VC Marques MEA. Lymphoepithelioma-like carcinoma of the skin. Anais Brasileiros de Dermatologia. 2018; 93: 256-258 Crossref PubMed Scopus (5) Google Scholar , 3 Wang G Bordeaux JS Rowe DJ Honda KS. Lymphoepithelioma-like carcinoma vs inflamed squamous cell carcinoma of the skin. JAMA Dermatol. 2014; 150: 1367-1368 Crossref PubMed Scopus (3) Google Scholar Lymphovascular space invasion is associated with a more aggressive phenotype 3 Wang G Bordeaux JS Rowe DJ Honda KS. Lymphoepithelioma-like carcinoma vs inflamed squamous cell carcinoma of the skin. JAMA Dermatol. 2014; 150: 1367-1368 Crossref PubMed Scopus (3) Google Scholar ; for this case, histologic comparison of the primary skin tumor and the excised neck lymph node is important, along with identification of high-risk features. A subset of lymphoepithelioma-like carcinomas arise from the nasopharynx and are Epistein Barr Virus positive; although the computed tomography revealed no metastases, we recommend fluorodeoxyglucose whole-body positron emission tomography-computed tomography and assessment of the nasopharynx for an occult primary. 2 Oliveira CC Nóbrega VC Marques MEA. Lymphoepithelioma-like carcinoma of the skin. Anais Brasileiros de Dermatologia. 2018; 93: 256-258 Crossref PubMed Scopus (5) Google Scholar A Real Pain In The NeckInternational Journal of Radiation Oncology, Biology, PhysicsVol. 113Issue 5PreviewA 63-year-old man noticed a pruritic mass on the back of his central/right neck, prompting a dermatologic biopsy revealing lymphoepithelioma-like carcinoma and subsequent wide local excision (8 cm × 4 cm) by otolaryngology, with negative margins. Postoperative management involved quarterly follow-up, with no adjuvant therapies recommended. Full-Text PDF