Produção Nacional
Revisado por pares
Prognosis of chronic Chagas heart disease and other pending clinical challenges
2022; Instituto Oswaldo Cruz, Ministério da Saúde; Volume: 117; Linguagem: Inglês
10.1590/0074-02760210172
ISSN1678-8060
AutoresRosália Morais Tôrres, Dalmo Correia, Maria do Carmo Pereira Nunes, Walderez O. Dutra, André Talvani, Andréa Silvestre de Sousa, Fernanda de Souza Nogueira Sardinha Mendes, Maurício Scanavacca, Cristiano Pisani, Maria da Consolação Vieira Moreira, Dilma do Socorro Moraes de Souza, Wilson de Oliveira, Sílvia Marinho Martins Alves, João Carlos Pinto Dias,
Tópico(s)Viral Infections and Immunology Research
ResumoIn this chapter, the main prognostic markers of Chagas heart disease are addressed, with an emphasis on the most recent findings and questions, establishing the basis for a broad discussion of recommendations and new approaches to managing Chagas cardiopathy. The main biological and genetic markers and the contribution of the electrocardiogram, echocardiogram and cardiac magnetic resonance are presented. We also discuss the most recent therapeutic proposals for heart failure, thromboembolism and arrhythmias, as well as current experience in heart transplantation in patients suffering from severe Chagas cardiomyopathy. The clinical and epidemiological challenges introduced by acute Chagas disease due to oral contamination are discussed. In addition, we highlight the importance of ageing and comorbidities in influencing the outcome of chronic Chagas heart disease. Finally, we discuss the importance of public policies, the vital role of funding agencies, universities, the scientific community and health professionals, and the application of new technologies in finding solutions for better management of Chagas heart disease.
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