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International Delphi consensus guidelines for follow-up after prophylactic total gastrectomy: the Life after Prophylactic Total Gastrectomy (LAP-TG) study

2022; Springer Science+Business Media; Volume: 25; Issue: 6 Linguagem: Inglês

10.1007/s10120-022-01318-5

1436-3305

Geoffrey Roberts, Patrick R. Benusiglio, Tanya M. Bisseling, Daniel G. Coit, Jeremy L. Davis, Sam Grimes, Theresa A. Guise, Richard Hardwick, Kirsty L Harris, Paul F. Mansfield, Jeremy Rossaak, Karen Chelcun Schreiber, Peter P. Stanich, Vivian E. Strong, Pardeep Kaurah, Julie Angel, Banu K. Arun, Manuela Baptista, Grant Beban, Ernst Jan Spillenaar Bilgen, Alex Boussioutas, Simone Busija, Carlos Caldas, Fátima Carneiro, Annemieke Cats, Maureen Connolly, Johanna L D'Addario, Massimiliano di Pietro, Cuong Duong, Naheed Farooq, Rebecca C. Fitzgerald, Claire Forde, Lauren A. Gamble, Kimberley Gamet, Irene Gullo, Trevor D. Hamilton, Nicoline Hoogerbrugge, Shannon Hopkins, Bryson W. Katona, Sonia S. Kupfer, Madison LaRose, Jéremie H. Lefèvre, Rachael Lopez, Julie Moskowitz, Kathryn Munder, Enrique Norero, Yann Parc, Karyn Paringatai, Susan Parry, Suraj Rajasimhan, Ross Roberts, Kasmintan A. Schrader, Carol E. Semrad, Ben Smith, Claire Smith, Fabiana Sousa, Elena M. Stoffel, Nicola Sunderland, Magali Svrcek, Marc Tischkowitz, Jolanda van Dieren, Bart Witteman, Yanghee Woo, Sam S. Yoon,

Esophageal Cancer Research and Treatment

Prophylactic total gastrectomy (PTG) remains the only means of preventing gastric cancer for people with genetic mutations predisposing to Hereditary Diffuse Gastric Cancer (HDGC), mainly in the CDH1 gene. The small but growing cohort of people undergoing PTG at a young age are expected to have a life-expectancy close to the general population, however, knowledge of the long-term effects of, and monitoring requirements after, PTG is limited. This study aims to define the standard of care for follow-up after PTG.Through a combination of literature review and two-round Delphi consensus of major HDGC/PTG units and physicians, and patient advocates, we produced a set of recommendations for follow-up after PTG.There were 42 first round, and 62 second round, responses from clinicians, allied health professionals and patient advocates. The guidelines include recommendations for timing of assessments and specialties involved in providing follow-up, micronutrient supplementation and monitoring, bone health and the provision of written information.While the evidence supporting the guidelines is limited, expert consensus provides a framework to best manage people following PTG, and could support the collection of information on the long-term effects of PTG.