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Immune responses in Omicron SARS-CoV-2 breakthrough infection in vaccinated adults

2022; Nature Portfolio; Volume: 13; Issue: 1 Linguagem: Inglês

10.1038/s41467-022-31888-y

2041-1723

Hassen Kared, Asia‐Sophia Wolf, Amin Alirezaylavasani, Anthony Ravussin, Guri Solum, Trung Tran, Fridtjof Lund‐Johansen, John Torgils Vaage, Lise Sofie Haug Nissen‐Meyer, Unni C. Nygaard, Olav Hungnes, Anna Hayman Robertson, Lisbeth Meyer Næss, Lill Trogstad, Per Magnus, Ludvig A. Munthe, Siri Mjaaland,

Vaccine Coverage and Hesitancy

The SARS-CoV-2 Omicron variant has more than 15 mutations in the receptor binding domain of the Spike protein enabling increased transmissibility and viral escape from antibodies in vaccinated individuals. It is unclear how vaccine immunity protects against Omicron infection. Here we show that vaccinated participants at a super-spreader event have robust recall response of humoral and pre-existing cellular immunity induced by the vaccines, and an emergent de novo T cell response to non-Spike antigens. Individuals with Omicron SARS-CoV-2 breakthrough infections have significantly increased activated SARS-CoV-2 wild type Spike-specific cytotoxic T cells, activated follicular helper (T