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Viral Vector Vaccine Development and Application during the COVID-19 Pandemic

2022; Multidisciplinary Digital Publishing Institute; Volume: 10; Issue: 7 Linguagem: Inglês

10.3390/microorganisms10071450

2076-2607

Shaofeng Deng, Hui Liang, Chen Pin, Yuwan Li, Zhaoyao Li, Shuangqi Fan, Keke Wu, Xiaowen Li, Wenxian Chen, Yuwei Qin, Lin Yi, Jinding Chen,

Vaccine Coverage and Hesitancy

With the accumulation of mutations in SARS-CoV-2 and the continuous emergence of new variants, the importance of developing safer and effective vaccines has become more prominent in combating the COVID-19 pandemic. Both traditional and genetically engineered vaccines have contributed to the prevention and control of the pandemic. However, in recent years, the trend of vaccination research has gradually transitioned from traditional to genetically engineered vaccines, with the development of viral vector vaccines attracting increasing attention. Viral vector vaccines have several unique advantages compared to other vaccine platforms. The spread of Omicron has also made the development of intranasal viral vector vaccines more urgent, as the infection site of Omicron is more prominent in the upper respiratory tract. Therefore, the present review focuses on the development of viral vector vaccines and their application during the COVID-19 pandemic.