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Molecular identification and risk factor analysis of the first Lumpy skin disease outbreak in cattle in Mongolia

2022; Japanese Society of Veterinary Science; Volume: 84; Issue: 9 Linguagem: Inglês

10.1292/jvms.22-0250

1347-7439

Odonchimeg Myagmarsuren, Erdenechimeg Dashzevge, Adiyasuren TUVSHINBAYAR, Munkhtuul Tsogtgerel, Enkhbold Bazarragchaa, Ulaankhuu Ankhanbaatar, Tsend Selenge, Dalantai Munkhgerel, Ariunbold Munkhtsetseg, Аltanchimeg Adilbish, Raadan Odbileg, Gurdorj Soyolmaa, Enkhmandakh Yondonjamts, Enkhbaatar Batmagnai, Sengee Sugar, Takashi Kimura, Chihiro Sugimoto, Norikazu Isoda, Basan Batsukh, Yoshihiro Sakoda,

Plant Virus Research Studies

Lumpy skin disease (LSD) is a transboundary viral infectious disease in cattle caused by a Capripoxvirus. LSD has been recently introduced in some Asian countries. However, in Mongolia, no report of LSD is publicly available. We clinically examined LSD symptoms in 1,034 cattle from 4 soum (district) in Dornod province in Mongolia. Sixty-one cattle of them were confirmed with symptoms of LSD and then viral P32 gene was detected by a PCR. The overall prevalence of LSD in cattle was 5.9%. Females odds ratios (OR) = 2.27 than males, adults (>2.5-years-old, OR = 3.68) than young (1–2.5-years-old) and calves (<1-year-old) were at higher risks for LSD cases in Mongolia, while locations near the tube well and pond water are major risk areas for viral transmission due to density of insects often is high. For virus isolation, skin nodule tissue samples of 4 cattle located in four distinct soums were used for viral propagation using the MDBK cell line. Internal terminal repeat region and RPO30 gene of 4 Mongolian isolates were amplified and sequenced. In the phylogenetic trees, Mongolian LSDVs (2021) were clustered together with the Chinese (2020) and Vietnamese isolates (2020). This is the first report alarming the LSD outbreak in Mongolia that was confirmed by our study. The newly isolated viruses would be a useful base for developing diagnostic tools and inactivated vaccine technology. A large-scale study of LSD is next priority for establishing successful control strategy of further disease outbreak.