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Cryo-electron tomography: A long journey to the inner space of cells

2022; Cell Press; Volume: 185; Issue: 15 Linguagem: Inglês

10.1016/j.cell.2022.06.034

1097-4172

Wolfgang Baumeister,

Advanced X-ray Imaging Techniques

Cryogenic electron tomography (cryo-ET) is the application of tomographic principles of data acquisition and reconstruction to frozen-hydrated biological specimens. It combines a close-to-life preservation of cellular structures with the power of high-resolution three-dimensional imaging, which allows us to study the molecular architecture of cells, or their molecular sociology, in unprecedented detail. Cryogenic electron tomography (cryo-ET) is the application of tomographic principles of data acquisition and reconstruction to frozen-hydrated biological specimens. It combines a close-to-life preservation of cellular structures with the power of high-resolution three-dimensional imaging, which allows us to study the molecular architecture of cells, or their molecular sociology, in unprecedented detail.