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BIBTEX RIS

Candidate genes for tick resistance in cattle: a systematic review combining post-GWAS analyses with sequencing data

2022; Taylor & Francis; Volume: 50; Issue: 1 Linguagem: Inglês

10.1080/09712119.2022.2096035

ISSN

0974-1844

Autores

Cassiane Gomes dos Santos, Mariele Freitas Sousa, João Inácio Gomes Vieira, Luana Rafaela de Morais, Aline Auxiliadora Silva Fernandes, Thayssa de Oliveira Littiere, Pamela Itajara Otto, Marco Antônio Machado, Marcos Vinícius Gualberto Barbosa da Silva, Cristina Moreira Bonafé, Ana Fabrícia Braga Magalhães, Lucas Lima Verardo,

Tópico(s)

Genetic Mapping and Diversity in Plants and Animals

Resumo

Rhipicephalus microplus causes huge losses in cattle. Host genetic background greatly affects the immune efficiency in resistance or susceptibility to tick infestation, which is one of the many factors that play a role on that trait. We performed a systematic review of genome-wide association studies (GWAS) for tick resistance in cattle resulting in 1353 candidate genes for post-GWAS analyses. From those, genes showing possible structural variants from the bovine genome were classified by the Variant Effect Predictor from Ensembl. Ninety-two candidate genes showed potential structural variants in 5′ UTR and coding region and were used for functional annotation. Enriched biological processes (e.g. regulation of eosinophil chemotaxis, RIG-I signalling pathway and monocyte differentiation) and candidate genes (e.g. DAPK2, PUM1, ACIN1, INPP5D) linked with immune system function were identified and thus associated with tick resistance. Besides, gene-transcription factors (TFs) networks were obtained from TFs associated with immune system (FOXO3, PPARG, STAT3, NFKB1, GATA3 and ARNT) and the candidate genes associated with tick resistance in cattle highlighted (e.g. OR4L1, PNP, LRRIQ1, GIMAP8, MYO6, MEP1A and LRFN2). Thus, promising candidate genes with a possible functional role for tick resistance in cattle are presented for further in vitro and/or in vivo analyses.

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