Produção Nacional
Revisado por pares
Hand, foot, and mouth disease outbreak by Coxsackievirus A6 during COVID-19 pandemic in 2021, São Paulo, Brazil.
2022; Elsevier BV; Volume: 154; Linguagem: Inglês
10.1016/j.jcv.2022.105245
ISSN1873-5967
AutoresR. Carmona, Bráulio Caetano Machado, Fabrício Caldeira Reis, Adriana M.V. Jorge, Audrey Cilli, Amanda Meireles Nunes Dias, Daniele Rita de Morais, Lucas Carvalho Leme, Ana Lúcia Frugis Yu, Marcela R. Silva, Telma Regina Marques Pinto Carvalhanas, Maria C.S.T. Timenetsky,
Tópico(s)Viral gastroenteritis research and epidemiology
ResumoHand, foot, and mouth disease (HFMD) is an acute febrile illness characterized by fever; sore throat; and vesicular eruptions on the hands, feet, and oral mucosa. Outbreaks of HFMD in children aged <5 years have been reported worldwide and the major causative agents are Coxsackievirus (CV)A16, enterovirus (EV)-A71 and recently CVA6.The aim of this study was to investigated a large outbreak of Hand, foot, and mouth disease during COVID-19 pandemic in 2021 from clinical samples of 315 suspected cases, in São Paulo State, Brazil. Diagnostic evaluation was performed by RT-qPCR, culture cell isolation and serological neutralization assay. EV-positive were genotyped by partial VP1 genome sequencing.One hundred and forty-nine cases analyzed were positive for enterovirus (47.3%; n = 149/315) by neutralizing test (n = 10 patients) and RT-qPCR (n = 139 patients), and identified as CVA6 sub-lineage D3 by analysis of VP1 partial sequences.This finding indicated the reemergence of CVA6 in HFMD, soon after the gradual easing of non-pharmaceutical interventions during-pandemic COVID-19 and the relevance of continued surveillance of circulating enterovirus types in the post-COVID pandemic era.
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