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Neutrophil to Lymphocyte Ratio in Patients With a First Episode of Psychosis: A Two-Year Longitudinal Follow-up Study

2022; Oxford University Press; Volume: 48; Issue: 6 Linguagem: Inglês

10.1093/schbul/sbac089

1745-1701

Miquel Bioque, Ana Catarina Matias-Martins, Vicent Llorca-Bofí, Gisela Mezquida, Manuel J. Cuesta, Eduard Vieta, Sílvia Amoretti, António Lobo, Ana González‐Pinto, Carmen Moreno, Alexandra Roldán, Anabel Martínez‐Arán, Immaculada Baeza, Daniel Bergé, Clemente García-Rizo, Sergi Mas, Miquel Bernardo, Santiago Madero, Jairo M. González-Díaz, Álvaro Andreu-Bernabeu, Sandra Recio, Judit Selma, Maria Tonda, Edurne García-Corres, Jéssica Fernández-Sevillano, Concepción De‐la‐Cámara, Pedro Modrego-Pardo, Ma José Escartí, Marta Pérez-Rando, Guillermo Vázquez, Sílvia Cristeto, José Sánchez‐Moreno, Anna Giménez‐Palomo, Josefina Castro‐Fornieles, Elena de la Serna, Fernando Hernández Contreras, Leticia González-Blanco, Pilar A. Sáiz, Miguel Gutiérrez‐Fraile, Arantzazu Zabala, Luis Sánchez-Pastor, Roberto Rodríguez‐Jiménez, Judith Usall, Anna Butjosa, Edith Pomarol‐Clotet, Salvador Sarró, Ángela Ibáñez, Ana M. Sánchez-Torres, Vicent Balanzá‐Martínez,

Bipolar Disorder and Treatment

Abstract Background and Hypothesis A pro-inflammatory phenotype has been related to psychotic disorders. The neutrophil-lymphocyte ratio (NLR) is an accessible biomarker that could be helpful to characterize this systemic inflammation state. Study Design This study evaluated the NLR in a cohort of 310 subjects with a first episode of psychosis (FEP) and a matched group of 215 healthy controls, recruited in 16 Spanish centers participating in the PEPs Project. We investigated the NLR measures over 2 years in a prospective, naturalistic study. Study Results At baseline, the FEP group showed a significant higher mean NLR compared to the control group (1.96 ± 1.11 vs 1.72 ± 0.74, P = 0.03). These ratio differences between groups grew at the 24 months follow-up visit (2.04 ± 0.86 vs 1.65 ± 0.65, P < 0.001). Within the FEP group, there were no significant differences in NLR across the follow-up visits, between genders or diagnosis groups (affective vs nonaffective). NLR values did not correlate with the Positive and Negative Symptoms Scale scores. The group of patients who did not reach remission criteria at the end of the study showed a significant higher NLR than those who remitted (2.1896 ± 0.85 vs 1.95 ± 0.87, P = 0.042). A significant correlation between antipsychotic doses and NLR was found at the two-years follow-up visit (r=0.461, P < 0.001). Conclusions Our results highlight the existence of an underlying predisposition of FEP patients to present an increased mean NLR. The use of NLR in clinical practice could be helpful to identify this inflammatory imbalance.