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Circadian Rhythm Dysregulation and Leukemia Development: The Role of Clock Genes as Promising Biomarkers

2022; Multidisciplinary Digital Publishing Institute; Volume: 23; Issue: 15 Linguagem: Inglês

10.3390/ijms23158212

1661-6596

Ana Beatriz Aguiar Sanford, Leidivan Sousa da Cunha, Caio Bezerra Machado, Flávia Melo Cunha de Pinho Pessoa, Abigail Nayara dos Santos Silva, Rodrigo Monteiro Ribeiro, Fabiano Cordeiro Moreira, Manoel Odorico de Moraes, Maria Elisabete Amaral de Moraes, Lucas Eduardo Botelho de Souza, André Salim Khayat, Caroline Aquino Moreira-Nunes,

Spaceflight effects on biology

The circadian clock (CC) is a daily system that regulates the oscillations of physiological processes and can respond to the external environment in order to maintain internal homeostasis. For the functioning of the CC, the clock genes (CG) act in different metabolic pathways through the clock-controlled genes (CCG), providing cellular regulation. The CC's interruption can result in the development of different diseases, such as neurodegenerative and metabolic disorders, as well as cancer. Leukemias correspond to a group of malignancies of the blood and bone marrow that occur when alterations in normal cellular regulatory processes cause the uncontrolled proliferation of hematopoietic stem cells. This review aimed to associate a deregulated CC with the manifestation of leukemia, looking for possible pathways involving CG and their possible role as leukemic biomarkers.