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BIBTEX RIS

Samanea tubulosa Benth. (Fabaceae): Antinociceptive effect on acute pain in mice: K+ATP channel and opioid activity

2022; Brazilian Academy of Sciences; Volume: 94; Issue: 2 Linguagem: Inglês

10.1590/0001-3765202220210175

ISSN

1678-2690

Autores

Tamnata Ferreira Alixandre, Renato Pinto de Sousa, Bruno da Silva Gomes, ARÊTHA H.S. SILVA, BENEDITO P. SOUSA NETO, Elcilene Alves de Sousa, Marluce Pereira Damasceno Lima, Everton Moraes Lopes, Celyane Alves Piauilino, Rejane Teixeira do Nascimento, Antonio Carlos dos Reis Filho, Fernanda Regina de Castro Almeida, Francisco de Assis Oliveira, Mariana Helena Chaves, Luciana Muratori Costa, Michel Muálem Moraes Alves, Amilton Paulo Raposo Costa,

Tópico(s)

Ion channel regulation and function

Resumo

Samanea tubulosa Benth. it has been widely used in traditional medicine to treat inflammatory processes. The present study aimed to investigate the antinociceptive effect and mechanism of action of the fractions obtained from the Samanea tubulosa pods in mice. The antinociceptive activity was evaluated in formalin, capsaicin and glutamate tests and the. The possible mechanisms of action involved in the antinociceptive effect of the hexane and ethyl acetate fraction in the opioid system, also the the K + ATP channels and the L-arigine pathways of nitric oxide were evaluated. The chemical characterization analysis revealed in the hexane fraction the presence of triterpenes such as lupenone and lupeol. In the glutamate test, the hexane and ethyl acetate fractions showed antinociceptive activity at the dose of 12.5 and 25 mg kg-1. The antinociception produced by the hexane and ethyl acetate fractions was significantly reversed by naloxone, indicating that the fractions act through the opioid pathway. Antinociceptive response of the ethyl acetate fraction was blocked by glibenclamide, indicating that this fraction acts via the K + ATP channels activation. It is concluded that the fractions under study exert antinociceptive activity possibly related to the opioid route and through K+ ATP channels activation.

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