Portal de Periódicos da CAPES

Antivirals With Activity Against Mpox: A Clinically Oriented Review

2022; Oxford University Press; Volume: 76; Issue: 1 Linguagem: Inglês

10.1093/cid/ciac622

1537-6591

Emily A Siegrist, Joseph Sassine,

Bacillus and Francisella bacterial research

Abstract Mpox virus is an emergent human pathogen. While it is less lethal than smallpox, it can still cause significant morbidity and mortality. In this review, we explore 3 antiviral agents with activity against mpox and other orthopoxviruses: cidofovir, brincidofovir, and tecovirimat. Cidofovir, and its prodrug brincidofovir, are inhibitors of DNA replication with a broad spectrum of activity against multiple families of double-stranded DNA viruses. Tecovirimat has more specific activity against orthopoxviruses and inhibits the formation of the extracellular enveloped virus necessary for cell-to-cell transmission. For each agent, we review basic pharmacology, data from animal models, and reported experience in human patients.