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Clinical Cure of a Difficult-to-Treat Resistant Pseudomonas aeruginosa Ventriculitis Using Cefiderocol: A Case Report and Literature Review

2022; Oxford University Press; Volume: 9; Issue: 8 Linguagem: Inglês

10.1093/ofid/ofac391

2328-8957

Cristina Marcelo, Alejandro de Gea Grela, María Martínez Palazuelos, Javier Veganzones, David Grandioso, Beatriz Díaz‐Pollán,

Pneumonia and Respiratory Infections

Abstract Ventriculitis is a complication of meningitis (community-acquired or nosocomial) or other central nervous system (CNS) infections such as brain abscess. They are associated with a different spectrum of microorganisms, from resistant gram-negative bacilli to staphylococci, that can lead serious illness with high mortality. Difficult-to-treat resistance (DTR) gram-negative bacilli may increase to 20% of deaths respective to susceptible isolates of the same bacteria. We present the first report of a clinical cured case of DTR Pseudomonas aeruginosa ventriculitis in which cefiderocol penetration into the CNS has been confirmed in blood and cerebrospinal fluid. Cefiderocol might be considered for difficult-to-treat CNS infections in view of the recent new cases published as well as our case.