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A Targeted Proteomics Approach for Screening Serum Biomarkers Observed in the Early Stage of Type I Endometrial Cancer

2022; Multidisciplinary Digital Publishing Institute; Volume: 10; Issue: 8 Linguagem: Inglês

10.3390/biomedicines10081857

2227-9059

Blendi Ura, Valeria Capaci, Michelangelo Aloisio, Giovanni Di Lorenzo, Federico Romano, Giuseppe Ricci, Lorenzo Monasta,

Molecular Biology Techniques and Applications

Endometrial cancer (EC) is the most common gynecologic malignancy, and it arises in the inner part of the uterus. Identification of serum biomarkers is essential for diagnosing the disease at an early stage. In this study, we selected 44 healthy controls and 44 type I EC at tumor stage 1, and we used the Immuno-oncology panel and the Target 96 Oncology III panel to simultaneously detect the levels of 92 cancer-related proteins in serum, using a proximity extension assay. By applying this methodology, we identified 20 proteins, associated with the outcome at binary logistic regression, with a