Portal de Periódicos da CAPES

Impact of different COVID-19 waves on kidney replacement therapy epidemiology and mortality: REMER 2020

2022; Oxford University Press; Volume: 37; Issue: 11 Linguagem: Inglês

10.1093/ndt/gfac234

1460-2385

Sol Carriazo, Manuel Ignacio Aparicio-Madre, Fernando Tornero-Molina, Milagros Fernández‐Lucas, Vicente Paraíso-Cuevas, Emilio González‐Parra, Francisco del Río-Gallegos, María Marqués, Roberto Alcázar Arroyo, Judith Martins, Rafael Sánchez, Beatriz Gil-Casares, Eduardo Gutiérrez-Martínez, María Pilar Martínez-Rubio, Alberto Ortíz, Maria Ángeles Goicoechea Diezhandino, María Luisa Rodríguez Ferrero, Soraya Abad Estébanez, Milagros Fernández Lucas, Nuria Rodríguez Mendiola, Martha Díaz Domínguez, Sandra Elías Triviño, Víctor Burguera Vion, Carlos Jiménez Martín, Auxiliadora Bajo Rubio, Rafael Selgas Gutiérrez, Á. Alonso Melgar, Laura Espinosa Román, José Pórtoles, Beatriz Sobrino, Rosario Llópez Carratalá, José Antonio Herrero Calvo, Isabel Flores, Ana Sánchez‐Fructuoso, Paula Jara Caro-Espada, Elena Gutiérrez Solís, Catalina Martín-Cleary, Ana Ramos Verde, Jesús Hernández Pérez, Guillermina Barril Cuadrado, Martín Giorgi González, Antonio Fernández Perpén, Cristina Bernis Carro, Patricia Martínez‐Miguel, María Fuensanta Moreno Barrio, Hanane Bouarich, María Pérez Fernández, Enrique Gruss Vergara, Gema Fernández‐Juárez, Eduardo Gallego Valcarce, Ana Tato Ribera, Juan Carlos Herrero Berrón, María Teresa Naya Nieto, Alfonso Cubas Alcaraz, Fernando Tornero Molina, Beatriz Gil-Casares Casanova, Elda Besada Estévez, Vicente Paraíso Cuevas, Jesús Benito García, Alicia García Pérez, Valeria Sáiz Prestel, Patricia de Sequera Ortiz, Rocío Echarri Carrillo, María Covadonga Hevia Ojanguren, María del Carmen Jiménez Herrero, Simona Alexandru, Saul Enrique Pampa Saíco, Rosa Sánchez Hernández, Rocío Zamora González-Mariño, Laura Rodríguez-Osorio Jiménez, Beatríz Durá Gúrpide, Elisa Ruiz Cícero, Cristina Albarracín Sierra, Ramón Delgado Lillo, M Yagüe, D Jorge Valencia Alonso, Raquel Gota Ángel, Aurelio Sanz Guajardo, Carlos Jiménez Martín, Jesús Hernández Pérez, Karina Ruth Furaz Czerpak, Ángel Agustín Méndez Abreu, Ana Botella Lorenzo, Javier Naranjo Sanz, María Teresa Villaverde Ares, Sandra Castellano Gasch, María del Pilar Martínez Rubio, Patricia Nora Estrada Villanueva, José Ramón Berlanga Alvarado, Ana María Blanco Santos, Carmen Gámez Matías, Pablo Mateos Hernández, Marta Sanz Sainz,

COVID-19 Clinical Research Studies

Kidney replacement therapy (KRT) confers the highest risk of death from coronavirus disease 2019 (COVID-19). However, most data refer to the early pandemic waves. Whole-year analysis compared with prior secular trends are scarce.We present the 2020 REMER Madrid KRT registry, corresponding to the Spanish Region hardest hit by COVID-19.In 2020, KRT incidence decreased 12% versus 2019, while KRT prevalence decreased by 1.75% for the first time since records began and the number of kidney transplants (KTs) decreased by 16%. Mortality on KRT was 10.2% (34% higher than the mean for 2008-2019). The 2019-2020 increase in mortality was larger for KTs (+68%) than for haemodialysis (+24%) or peritoneal dialysis (+38%). The most common cause of death was infection [n = 419 (48% of deaths)], followed by cardiovascular [n = 200 (23%)]. Deaths from infection increased by 167% year over year and accounted for 95% of excess deaths in 2020 over 2019. COVID-19 was the most common cause of death (68% of infection deaths, 33% of total deaths). The bulk of COVID-19 deaths [209/285 (73%)] occurred during the first COVID-19 wave, which roughly accounted for the increased mortality in 2020. Being a KT recipient was an independent risk factor for COVID-19 death.COVID-19 negatively impacted the incidence and prevalence of KRT, but the increase in KRT deaths was localized to the first wave of the pandemic. The increased annual mortality argues against COVID-19 accelerating the death of patients with short life expectancy and the temporal pattern of COVID-19 mortality suggests that appropriate healthcare may improve outcomes.