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Inflammatory biomarkers and risk of breast cancer among young women in Latin America: a case-control study

2022; BioMed Central; Volume: 22; Issue: 1 Linguagem: Inglês

10.1186/s12885-022-09975-6

1471-2407

Emma Fontvieille, Mathilde His, Carine Biessy, Anne‐Sophie Navionis, Gabriela Torres-Mejı́a, Angélica Ángeles-Llerenas, Isabel Alvarado‐Cabrero, Gloria Inés Sánchez, Édgar Navarro, Yorlany Rodas Cortés, Carolina Porras, Ana Cecilia Rodríguez, María Luisa Garmendia, José Luis Soto, Leonor Moyano, Peggy L. Porter, Ming Gang Lin, Jamie Guenthoer, Isabelle Romieu, Sabina Rinaldi, Jenny Tejeda, María Felix Lazcano, Libia Zulema Franco, Roberto Jaramillo, Alberto Angel, Carlos Andrés Ossa, William Arias, Gabriel Bedoya, Alicia Cock‐Rada, Carolina Echeverri, Fernando Herazo, Israel Díaz-Yúnez, Angel Hernández, Bernal Cortés, Paula González, Rebecca Ocampo, Diego Guillén, Viviana Loría, Catalina Vial, L. Díaz, Elizabeth Donato, Thomas Donn, Kelly Wirtala, Hailey Loucks,

Estrogen and related hormone effects

Abstract Background Breast cancer incidence is increasing rapidly in Latin America, with a higher proportion of cases among young women than in developed countries. Studies have linked inflammation to breast cancer development, but data is limited in premenopausal women, especially in Latin America. Methods We investigated the associations between serum biomarkers of chronic inflammation (interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), leptin, adiponectin) and risk of premenopausal breast cancer among 453 cases and 453 matched, population-based controls from Chile, Colombia, Costa Rica, and Mexico. Odds ratios (OR) were estimated using conditional logistic regression models. Analyses were stratified by size and hormonal receptor status of the tumors. Results IL-6 (OR per standard deviation (SD) = 1.33 (1.11–1.60)) and TNF-α (OR per SD = 1.32 (1.11–1.58)) were positively associated with breast cancer risk in fully adjusted models. Evidence of heterogeneity by estrogen receptor (ER) status was observed for IL-8 (P-homogeneity = 0.05), with a positive association in ER-negative tumors only. IL-8 (P-homogeneity = 0.06) and TNF-α (P-homogeneity = 0.003) were positively associated with risk in the largest tumors, while for leptin (P-homogeneity = 0.003) a positive association was observed for the smallest tumors only. Conclusions The results of this study support the implication of chronic inflammation in breast cancer risk in young women in Latin America. Largest studies of prospective design are needed to confirm these findings in premenopausal women.