Produção Nacional
Revisado por pares
Genomic epidemiology of the SARS-CoV-2 epidemic in Brazil
2022; Nature Portfolio; Volume: 7; Issue: 9 Linguagem: Inglês
10.1038/s41564-022-01191-z
ISSN2058-5276
AutoresMarta Giovanetti, Svetoslav Nanev Slavov, Vagner Fonseca, Eduan Wilkinson, Houriiyah Tegally, José Salvatore Leister Patané, Vincent Louis Viala, James Emmanuel San, Evandra Strazza Rodrigues, Elaine Vieira Santos, Flávia Figueira Aburjaile, Joilson Xavier, Hegger Fritsch, Talita Adelino, Felicidade Mota Pereira, Arabela Leal, Felipe Campos de Melo Iani, Glauco de Carvalho Pereira, Cynthia Vázquez, Gladys Mercedes Estigarribia Sanabria, Elaine Cristina de Oliveira, Luiz Henrique Ferraz Demarchi, Júlio Croda, Rafael dos Santos Bezerra, Loyze Paola Oliveira de Lima, Antonio Jorge Martins, Cláudia Renata dos Santos Barros, Elaine Cristina Marqueze, Jardelina de Souza Todão Bernardino, Débora Botéquio Moretti, Ricardo Augusto Brassaloti, Raquel de Lello Rocha Campos Cassano, Pilar Mariani, João Paulo Kitajima, Bibiana Santos, Rodrigo Proto‐Siqueira, Vlademir Vicente Cantarelli, Stephane Tosta, Vanessa Brandão Nardy, Luciana Reboredo de Oliveira da Silva, Marcela Gómez, Jaqueline Gomes Lima, Adriana Aparecida Ribeiro, Natália Rocha Guimarães, Luiz Takao Watanabe, Luana Barbosa Da Silva, Raquel da Silva Ferreira, Mara Patricia F. da Penha, María José Cilleruelo Ortega, Andrea Gómez de la Fuente, Shirley Villalba, Juan Torales, María Liz Gamarra, Carolina Aquino, Gloria Patricia Martínez Figueredo, Wellington Santos Fava, Ana Rita Coimbra Motta-Castro, James Venturini, Sandra Maria do Valle Leone de Oliveira, Crhistinne Cavalheiro Maymone Gonçalves, Maria do Carmo Debur Rossa, Guilherme Becker, Mayra Presibella Giacomini, Nelson Quallio Marques, Irina Nastassja Riediger, Sônia Mara Raboni, Gabriela Mattoso Coelho, Allan D. Cataneo, Camila Zanluca, Claudia Nunes Duarte dos Santos, Patrícia Akemi Assato, Felipe Allan da Silva da Costa, Mirele Poleti, Jéssika Cristina Chagas Lesbon, E. C. Mattos, Cecília Ártico Banho, Lívia Sacchetto, Marília Mazzi Moraes, Rejane Maria Tommasini Grotto, Jayme A. Souza‐Neto, Maurício Lacerda Nogueira, Heidge Fukumasu, Luiz Lehmann Coutinho, Rodrigo T. Calado, Raul Machado Neto, Ana María Bispo de Filippis, Rivaldo Venâncio da Cunha, Carla Freitas, Cássio Peterka, Cássia de Fátima Rangel Fernandes, Wildo Navegantes, Rodrigo Fabiano do Carmo Said, Carlos F. Campelo de A e Melo, María Almirón, José Lourenço, Túlio de Oliveira, Edward C. Holmes, Ricardo Haddad, Sandra Coccuzzo Sampaio, Maria Carolina Elias, Simone Kashima, Luíz Carlos Júnior Alcântara, Dimas Tadeu Covas,
Tópico(s)Plant Virus Research Studies
ResumoAbstract The high numbers of COVID-19 cases and deaths in Brazil have made Latin America an epicentre of the pandemic. SARS-CoV-2 established sustained transmission in Brazil early in the pandemic, but important gaps remain in our understanding of virus transmission dynamics at a national scale. We use 17,135 near-complete genomes sampled from 27 Brazilian states and bordering country Paraguay. From March to November 2020, we detected co-circulation of multiple viral lineages that were linked to multiple importations (predominantly from Europe). After November 2020, we detected large, local transmission clusters within the country. In the absence of effective restriction measures, the epidemic progressed, and in January 2021 there was emergence and onward spread, both within and abroad, of variants of concern and variants under monitoring, including Gamma (P.1) and Zeta (P.2). We also characterized a genomic overview of the epidemic in Paraguay and detected evidence of importation of SARS-CoV-2 ancestor lineages and variants of concern from Brazil. Our findings show that genomic surveillance in Brazil enabled assessment of the real-time spread of emerging SARS-CoV-2 variants.
Referência(s)