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Flexible regulation of reactive oxygen species by sustainable cluster drugs

2022; Elsevier BV; Volume: 26; Linguagem: Inglês

10.1016/j.mtchem.2022.101093

2468-5194

Dan Li, Pengfei Zhuang, Xifan Mei,

Nanoplatforms for cancer theranostics

The lack of water solubility, the flexibility of drug response, and organ barrier penetrability are the drawbacks of many reactive oxygen species (ROS)-controlling nanomedicines. Although smart nano-delivery systems partially solve these problems, such systems require complex functionalization processes by loading additional drugs. On the other hand, metal nanoclusters (NCs) are simple in structure, consisting of only metalcore and stabilized ligands, but they can efficiently regulate ROS levels for various diseases. NCs do not require the additional loading of drugs but are biocompatible directly, which can pass through various organ barriers without further modification and be effectively excreted from the body without causing environmental burdens. Herein, we summarize the mechanism for regulation of ROS by NCs including the enzymatic and non-enzymatic systems. The regulatory propensity of ROS by amplifying, switching, or altering the enzyme-like activities based on tuning the metal cores and their surfaces is deeply discussed. Furthermore, the treatment of ROS-related diseases by NCs is presented. Finally, the prospect of better use of NCs to modulate ROS to improve biological fate is also proposed.