Produção Nacional
Revisado por pares
Drug Repurposing Based on Protozoan Proteome: In Vitro Evaluation of In Silico Screened Compounds against Toxoplasma gondii
2022; Multidisciplinary Digital Publishing Institute; Volume: 14; Issue: 8 Linguagem: Inglês
10.3390/pharmaceutics14081634
ISSN1999-4923
AutoresDébora Chaves Cajazeiro, Paula Pereira Marques Toledo, Natália Ferreira de Sousa, Marcus Tullius Scotti, Juliana Quero Reimão,
Tópico(s)Hepatitis B Virus Studies
Resumois a protozoan that infects up to a third of the world's population. This parasite can cause serious problems, especially if a woman is infected during pregnancy, when toxoplasmosis can cause miscarriage, or serious complications to the baby, or in an immunocompromised person, when the infection can possibly affect the patient's eyes or brain. To identify potential drug candidates that could counter toxoplasmosis, we selected 13 compounds which were pre-screened in silico based on the proteome of
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