Decarboxylative Cross-Coupling: A Radical Tool in Medicinal Chemistry
2022; American Chemical Society; Volume: 13; Issue: 9 Linguagem: Inglês
10.1021/acsmedchemlett.2c00286
ISSN1948-5875
AutoresGabriele Laudadio, Maximilian D. Palkowitz, Tamara El‐Hayek Ewing, Phil S. Baran,
Tópico(s)Catalytic Cross-Coupling Reactions
ResumoCarboxylic acids, the most versatile and ubiquitous diversity input used in medicinal chemistry for canonical polar bond constructions such as amide synthesis, can now be employed in a fundamentally different category of reaction to make C-C bonds by harnessing the power of radicals. This outlook serves as a user-guide to aid practitioners in both the design of syntheses that leverage the simplifying power of this disconnection and the precise tactics that can be employed to enable them. Taken together, this emerging area holds the potential to rapidly accelerate access to chemical space of value to modern medicinal chemistry.
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