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Premature aging of the immune system affects the response to SARS-CoV-2 mRNA vaccine in β-thalassemia: role of an additional dose

2022; Elsevier BV; Volume: 140; Issue: 15 Linguagem: Inglês

10.1182/blood.2022017594

1528-0020

Rita Carsetti, Chiara Agrati, Valeria Maria Pinto, Barbara Gianesin, Rita Gamberini, Monica Fortini, Susanna Barella, Rita Denotti, Silverio Perrotta, Maddalena Casale, Aurelio Maggio, Lorella Pitrolo, Eleonora Tartaglia, Eva Piano Mortari, Francesca Colavita, Vincenzo Puro, Massimo Francalancia, Valéria Marini, Marco Caminati, Filippo Mazzi, Lucia De Franceschi, Gian Luca Forni, Franco Locatelli,

COVID-19 Clinical Research Studies

Letter to Blood| October 13, 2022 Premature aging of the immune system affects the response to SARS-CoV-2 mRNA vaccine in β-thalassemia: role of an additional dose Clinical Trials & Observations Rita Carsetti, Rita Carsetti B-Cell Laboratory, Immunology Research Area, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Bambino Gesù Children’s Hospital, Rome, Italy https://orcid.org/0000-0002-2632-1078 Search for other works by this author on: This Site PubMed Google Scholar Chiara Agrati, Chiara Agrati Laboratory of Cellular Immunology, IRCCS, INMI L. Spallanzani, Rome, Italy Search for other works by this author on: This Site PubMed Google Scholar Valeria Maria Pinto, Valeria Maria Pinto Center for Microcythemia, Congenital Anemia, and Iron Dysmetabolism, Galliera Hospital, Genoa, Italy https://orcid.org/0000-0002-8375-6289 Search for other works by this author on: This Site PubMed Google Scholar Barbara Gianesin, Barbara Gianesin Center for Microcythemia, Congenital Anemia, and Iron Dysmetabolism, Galliera Hospital, Genoa, ItalyForAnemia Foundation, Genoa, Italy Search for other works by this author on: This Site PubMed Google Scholar Rita Gamberini, Rita Gamberini Day Hospital della Talassemia e delle Emoglobinopatie, Dipartimento di Medicina, Azienda Ospedaliero-Universitaria S. Anna, Cona di Ferrara, Ferrara, Italy Search for other works by this author on: This Site PubMed Google Scholar Monica Fortini, Monica Fortini Day Hospital della Talassemia e delle Emoglobinopatie, Dipartimento di Medicina, Azienda Ospedaliero-Universitaria S. Anna, Cona di Ferrara, Ferrara, Italy https://orcid.org/0000-0001-8406-0024 Search for other works by this author on: This Site PubMed Google Scholar Susanna Barella, Susanna Barella SSD Talassemia, Ospedale Pediatrico Microcitemico “A. Cao”, ASL8, Cagliari, Italy Search for other works by this author on: This Site PubMed Google Scholar Rita Denotti, Rita Denotti SSD Talassemia, Ospedale Pediatrico Microcitemico “A. Cao”, ASL8, Cagliari, Italy Search for other works by this author on: This Site PubMed Google Scholar Silverio Perrotta, Silverio Perrotta Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica, Università, degli Studi della Campania “Luigi Vanvitelli”, Napoli, Italy https://orcid.org/0000-0001-6149-6845 Search for other works by this author on: This Site PubMed Google Scholar Maddalena Casale, Maddalena Casale Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica, Università, degli Studi della Campania “Luigi Vanvitelli”, Napoli, Italy Search for other works by this author on: This Site PubMed Google Scholar Aurelio Maggio, Aurelio Maggio Campus of Hematology Franco and Piera Cutino, AOOR Villa Sofia-V. Cervello, Palermo, Italy Search for other works by this author on: This Site PubMed Google Scholar Lorella Pitrolo, Lorella Pitrolo Campus of Hematology Franco and Piera Cutino, AOOR Villa Sofia-V. Cervello, Palermo, Italy Search for other works by this author on: This Site PubMed Google Scholar Eleonora Tartaglia, Eleonora Tartaglia Laboratory of Cellular Immunology, IRCCS, INMI L. Spallanzani, Rome, Italy https://orcid.org/0000-0001-5773-7781 Search for other works by this author on: This Site PubMed Google Scholar Eva Piano Mortari, Eva Piano Mortari B-Cell Laboratory, Immunology Research Area, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Bambino Gesù Children’s Hospital, Rome, Italy https://orcid.org/0000-0002-0054-4732 Search for other works by this author on: This Site PubMed Google Scholar Francesca Colavita, Francesca Colavita Laboratory of Virology, IRCCS, INMI L. Spallanzani, IRCCS, Rome, Italy Search for other works by this author on: This Site PubMed Google Scholar Vincenzo Puro, Vincenzo Puro Risk Management and Biosafety Unit, IRCCS, INMI L Spallanzani, Rome, Italy Search for other works by this author on: This Site PubMed Google Scholar Massimo Francalancia, Massimo Francalancia Laboratory of Virology, IRCCS, INMI L. Spallanzani, IRCCS, Rome, Italy https://orcid.org/0000-0003-3133-9237 Search for other works by this author on: This Site PubMed Google Scholar Valeria Marini, Valeria Marini Clinical Pharmacology Unit, EO Ospedali Galliera, Genoa, ItalyPharmacology & Toxicology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy Search for other works by this author on: This Site PubMed Google Scholar Marco Caminati, Marco Caminati Department of Medicine, University of Verona & AOUI Verona, Policlinico GB Rossi, Verona, Italy https://orcid.org/0000-0001-7383-1487 Search for other works by this author on: This Site PubMed Google Scholar Filippo Mazzi, Filippo Mazzi Department of Medicine, University of Verona & AOUI Verona, Policlinico GB Rossi, Verona, Italy Search for other works by this author on: This Site PubMed Google Scholar Lucia De Franceschi, Lucia De Franceschi Department of Medicine, University of Verona & AOUI Verona, Policlinico GB Rossi, Verona, Italy https://orcid.org/0000-0001-7093-777X Search for other works by this author on: This Site PubMed Google Scholar Gian Luca Forni, Gian Luca Forni Center for Microcythemia, Congenital Anemia, and Iron Dysmetabolism, Galliera Hospital, Genoa, Italy https://orcid.org/0000-0001-9833-1016 Search for other works by this author on: This Site PubMed Google Scholar Franco Locatelli Franco Locatelli Department of Pediatric Hematology and Oncology, IRCCS Bambino Gesù Children’s Hospital, Catholic University of the Sacred Heart, Rome, Italy Search for other works by this author on: This Site PubMed Google Scholar Blood (2022) 140 (15): 1735–1738. https://doi.org/10.1182/blood.2022017594 Article history Submitted: June 30, 2022 Accepted: August 11, 2022 First Edition: August 24, 2022 Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Request Permissions Cite Icon Cite Search Site Citation Rita Carsetti, Chiara Agrati, Valeria Maria Pinto, Barbara Gianesin, Rita Gamberini, Monica Fortini, Susanna Barella, Rita Denotti, Silverio Perrotta, Maddalena Casale, Aurelio Maggio, Lorella Pitrolo, Eleonora Tartaglia, Eva Piano Mortari, Francesca Colavita, Vincenzo Puro, Massimo Francalancia, Valeria Marini, Marco Caminati, Filippo Mazzi, Lucia De Franceschi, Gian Luca Forni, Franco Locatelli; Premature aging of the immune system affects the response to SARS-CoV-2 mRNA vaccine in β-thalassemia: role of an additional dose. Blood 2022; 140 (15): 1735–1738. doi: https://doi.org/10.1182/blood.2022017594 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBlood Search Subjects: Clinical Trials and Observations, Free Research Articles, Red Cells, Iron, and Erythropoiesis TO THE EDITOR: Patients with β-thalassemia show 5-fold increase in age-standardized lethality due to SARS-CoV-2 infection, representing a high-risk population compared with age- and sex-matched healthy subjects.1 Vaccination against SARS-CoV-2 is crucial to reduce mortality and morbidity of frail patients.2 Up to now, limited data have been available on the responses of patients with β-thalassemia immunized with anti–SARS-CoV-2 mRNA vaccines.3 The main aim of the present prospective multicenter study was to evaluate the immunogenicity of the SARS-CoV-2 mRNA vaccine BNT162b2 in patients with transfusion-dependent β-thalassemia (TDT). Patients with TDT (n = 154), vaccinated within the Nationwide Vaccination Program in Italy, were enrolled in 7 comprehensive Italian centers for hemoglobinopathies. Serum samples were collected before vaccination (T0), 2 weeks after the second dose (T1), 12 weeks after the second dose (T2), before the third dose (T3), and at 4... References 1.Longo F, Gianesin B, Voi V, et al. Italian patients with hemoglobinopathies exhibit a 5-fold increase in age-standardized lethality due to SARS-CoV-2 infection. Am J Hematol. 2022;97(2):E75-E78.Google ScholarCrossrefSearch ADS PubMed 2.Oosting SF, van der Veldt AAM, Fehrmann RSN, et al. Immunogenicity after second and third mRNA-1273 vaccination doses in patients receiving chemotherapy, immunotherapy, or both for solid tumours. Lancet Oncol. 2022;23(7):833-835.Google ScholarCrossrefSearch ADS PubMed 3.Delaporta P, Terpos E, Solomou EE, et al. 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