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BIBTEX RIS

A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestine

2022; Associação Brasileira de Divulgação Científica; Volume: 55; Linguagem: Inglês

10.1590/1414-431x2022e11910

ISSN

1414-431X

Autores

Gabriela Mandú Gimenes, Giovanna O. Santana, Maria Vitória Martins Scervino, Rui Curi, Joice Naiara Bertaglia Pereira,

Tópico(s)

Gut microbiota and health

Resumo

The Goto-Kakizaki (GK) rat is a non-obese experimental model of type 2 diabetes mellitus (T2DM) that allows researchers to monitor diabetes-induced changes without jeopardizing the effects of obesity. This rat strain exhibits notable gastrointestinal features associated with T2DM, such as marked alterations in intestinal morphology, reduced intestinal motility, slow transit, and modified microbiota compared to Wistar rats. The primary treatments for diabetic patients include administration of hypoglycemic agents and insulin, and lifestyle changes. Emerging procedures, including alternative therapies, metabolic surgeries, and modulation of the intestinal microbiota composition, have been shown to improve the diabetic state of GK rats. This review describes the morpho-physiological diabetic-associated features of the gastrointestinal tract (GIT) of GK rats. We also describe promising strategies, e.g., metabolic surgery and modulation of gut microbiota composition, used to target the GIT of this animal model to improve the diabetic state.

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