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Waning of antibody levels induced by a 13-valent pneumococcal conjugate vaccine, using a 3 + 0 schedule, within the first year of life among children younger than 5 years in Blantyre, Malawi: an observational, population-level, serosurveillance study

2022; Elsevier BV; Volume: 22; Issue: 12 Linguagem: Inglês

10.1016/s1473-3099(22)00438-8

1474-4457

Todd D. Swarthout, Marc Henrion, Deus Thindwa, James Meiring, Maurice Mbewe, Akuzike Kalizang’oma, Comfort Brown, Jacquline Msefula, Brewster Moyo, Andrew A. Mataya, Susanne Barnaba, Emma Pearce, Melita A. Gordon, David Goldblatt, Neil French, Robert S. Heyderman,

Influenza Virus Research Studies

Pneumococcal conjugate vaccines (PCVs) induce serotype-specific IgG antibodies, effectively reducing vaccine-serotype carriage and invasive pneumococcal disease (IPD). IgG production wanes approximately 1 month after vaccination in absence of serotype-specific exposure. With uncertainty surrrounding correlate of protection (CoP) estimates and with persistent vaccine-serotype carriage and vaccine-serotype IPD after PCV13 introduction, we aimed to profile population-level immunogenicity among children younger than 5 years in Blantyre, Malawi.