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Autoradiographic localization of sigma opioid receptors in the gastrointestinal tract of the guinea pig

1989; Elsevier BV; Volume: 97; Issue: 1 Linguagem: Inglês

10.1016/0016-5085(89)91418-2

1528-0012

Fran�ois J. Roman, Lionel Buéno, G. Chomette, J.L. Junien, Station de Pharmacologie-Toxicologie,

Receptor Mechanisms and Signaling

The distribution of sigma and phencyclindine binding sites in the gastrointestinal tract of the guinea pig was studied by autoradiography after in vitro incubation of tissue slices with (+)3H-SKF 10,047 and 3H-1-1-[(2-thienyl)cyclohexyl] piperidine to locate sigma and phencyclidine receptors, respectively. A dense distribution of sigma binding sites was observed in the mucosa and in the submucosal plexus, particularly at the level of the fundus and duodenum. Muscular layers were only marginally labeled. No phencyclidine binding site could be demonstrated in any area. This selective distribution suggests a functional role of sigma receptors mainly in the control of endocrine or exocrine secretions, or both.