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Quality by Design-Driven Zeta Potential Optimisation Study of Liposomes with Charge Imparting Membrane Additives

2022; Multidisciplinary Digital Publishing Institute; Volume: 14; Issue: 9 Linguagem: Inglês

10.3390/pharmaceutics14091798

1999-4923

Zsófia Németh, Ildikó Csóka, Reza Semnani Jazani, Bence Sipos, Henrik Haspel, Gábor Kozma, Zoltán Kónya, Dorina Gabriella Dobó,

Nanoparticle-Based Drug Delivery

Liposomal formulations, as versatile nanocarrier systems suitable for targeted delivery, have a highly focused role in the therapy development of unmet clinical needs and diagnostic imaging techniques. Formulating nanomedicine with suitable zeta potential is an essential but challenging task. Formulations with a minimum ±30 mV zeta potential are considered stable. The charge of the phospholipid bilayer can be adjusted with membrane additives. The present Quality by Design-derived study aimed to optimise liposomal formulations prepared via the thin-film hydration technique by applying stearylamine (SA) or dicetyl phosphate (DCP) as charge imparting agents. This 3