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Purinergic Signaling during Inflammation

2012; Massachusetts Medical Society; Volume: 367; Issue: 24 Linguagem: Inglês

10.1056/nejmra1205750

1533-4406

Holger K. Eltzschig, Michail V. Sitkovsky, Simon C. Robson,

Calcium signaling and nucleotide metabolism

Receptors for ATP and ADP and adenosine exert various effects. ATP and ADP signaling is mainly proinflammatory, and adenosine signaling is mainly antiinflammatory. Receptors for these nucleosides are emerging as therapeutic targets in a number of inflammatory and autoimmune diseases.