Artigo Revisado por pares

Antiinflammatory activity of a COOH‐terminal fragment of the neuropeptide α‐MSH

1989; Wiley; Volume: 3; Issue: 11 Linguagem: Inglês

10.1096/fasebj.3.11.2550304

ISSN

1530-6860

Autores

Melanie E. Hiltz, James M. Lipton,

Tópico(s)

Biochemical effects in animals

Resumo

The FASEB JournalVolume 3, Issue 11 p. 2282-2284 Research Communications Antiinflammatory activity of a COOH-terminal fragment of the neuropeptide α-MSH Melanie E. Hiltz, Melanie E. Hiltz Departments of Physiology and Anesthesiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, 75235 USASearch for more papers by this authorJames M. Lipton, Corresponding Author James M. Lipton n/[email protected] Departments of Physiology and Anesthesiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, 75235 USATo whom correspondence should be addressed: Departments of Physiology and Anesthesiology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX 75235-9040, USA.Search for more papers by this author Melanie E. Hiltz, Melanie E. Hiltz Departments of Physiology and Anesthesiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, 75235 USASearch for more papers by this authorJames M. Lipton, Corresponding Author James M. Lipton n/[email protected] Departments of Physiology and Anesthesiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, 75235 USATo whom correspondence should be addressed: Departments of Physiology and Anesthesiology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX 75235-9040, USA.Search for more papers by this author First published: 01 September 1989 https://doi.org/10.1096/fasebj.3.11.2550304Citations: 53AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract The endogenous neuropeptide α-melanocyte stimulating hormone (α-MSH 1-13), previously found to have marked antipyretic activity, inhibits histamine-induced increases in vasopermeability. The primary antipyretic amino acid message sequence is believed to be the COOH-terminal trieptide, lysine-proline-valine. In recent preliminary research this tripeptide inhibited increases in vasopermeability, raising the possibility that this portion of the α-MSH molecule has general antiinflammatory activity. To test this idea, the effects of graded doses of α-MSH [11-13] on ear swelling induced by picryl chloride in mice were compared with the effects of saline and a large dose of corticosteroid. α-MSH [11-13] inhibited swelling in a dose-related fashion. This result, together with previous findings, suggests that endogenous circulating α-MSH and its COOH-terminal fragments may contribute to modulation of physiological responses in host defense. If this is true, it may be possible to develop new peptide drugs or mimetics based on the tripeptide that are useful in treating inflammation.— Hiltz, M. E.; Lipton, J. M. Antiinflammatory activity of a COOH-terminal fragment of the neuropeptide α-MSH. FASEB J. 3: 2282-2284; 1989. Citing Literature Volume3, Issue11September 1989Pages 2282-2284 RelatedInformation

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