Portal de Periódicos da CAPES

Kinetics of humoral immune response over 17 months of COVID-19 pandemic in a large cohort of healthcare workers in Spain: the ProHEpiC-19 study

2022; BioMed Central; Volume: 22; Issue: 1 Linguagem: Inglês

10.1186/s12879-022-07696-6

1471-2334

Concepción Violán, Pere Torán‐Monserrat, Bibiana Quirant, Noemí Lamonja-Vicente, Lucía A. Carrasco‐Ribelles, Carla Chacón, Josep Maria Manresa‐Domínguez, Francesc Ramos‐Roure, Rosalía Dacosta‐Aguayo, Cristina Palacios-Fernández, Albert Roso‐Llorach, Aleix Pujol, Dan Ouchi, Mónica Monteagudo, Pilar Montero-Alía, Rosa García‐Sierra, Fernándo Arméstar, María Doladé, Núria Prat, Josep Maria Bonet, Bonaventura Clotet, Ignacio Blanco, Marc Boigues-Pons, Nemesio Moreno-Millán, Julia G. Prado, Eva María Martínez Cáceres, Marta Soldevilla Garcia, Ester Moral Roldan, Magda Alemany Costa, Eva Olivares Ortega, Alba Pachón-Camacho, Marta Bujalance Devesa, Mariella Soto Espinoza, Antonio Negrete Palma, Mariana Martinez de San José, Ester Lucas Varas, Ester Badia Perich, Mónica Piña Rodriguez, Elena Domenech Graells, Eduard Moreno‐Gabriel, Victòria Sabaté Cintas, Ma Jose Argerich González, Asumció Vazquez Duran, Alex Ortega Roca, Anna Devesa Pradells, Athina Kielpilanen, Oscar Blanch Lombarte, Miguel Ángel Marín, Julieta Carabelli, Ruth Peña Poderós, Esther Jimenez Moyano, Eulalia Grau Segura, Laia Bernard Rosa, Raul Pérez Caballero, Felipe Rodriguez Lozano, Gema Fernández Rivas, Sònia Molinos Abós, Jaume Barallat Martinez de Osaba, Lorena Tello Trigo, Cristina Perez Cano, Juan Matllo Aguilar, Anabel López Martínez, Inmaculada Agüera Iglesias,

COVID-19 epidemiological studies

Understanding the immune response to the SARS-CoV-2 virus is critical for efficient monitoring and control strategies. The ProHEpic-19 cohort provides a fine-grained description of the kinetics of antibodies after SARS-CoV-2 infection with an exceptional resolution over 17 months.We established a cohort of 769 healthcare workers including healthy and infected with SARS-CoV-2 in northern Barcelona to determine the kinetics of the IgM against the nucleocapsid (N) and the IgG against the N and spike (S) of SARS-CoV-2 in infected healthcare workers. The study period was from 5 May 2020 to 11 November 2021.We used non-linear mixed models to investigate the kinetics of IgG and IgM measured at nine time points over 17 months from the date of diagnosis. The model included factors of time, gender, and disease severity (asymptomatic, mild-moderate, severe-critical) to assess their effects and their interactions.474 of the 769 participants (61.6%) became infected with SARS-CoV-2. Significant effects of gender and disease severity were found for the levels of all three antibodies. Median IgM(N) levels were already below the positivity threshold in patients with asymptomatic and mild-moderate disease at day 270 after the diagnosis, while IgG(N and S) levels remained positive at least until days 450 and 270, respectively. Kinetic modelling showed a general rise in both IgM(N) and IgG(N) levels up to day 30, followed by a decay with a rate depending on disease severity. IgG(S) levels remained relatively constant from day 15 over time.IgM(N) and IgG(N, S) SARS-CoV-2 antibodies showed a heterogeneous kinetics over the 17 months. Only the IgG(S) showed a stable increase, and the levels and the kinetics of antibodies varied according to disease severity. The kinetics of IgM and IgG observed over a year also varied by clinical spectrum can be very useful for public health policies around vaccination criteria in adult population.Regional Ministry of Health of the Generalitat de Catalunya (Call COVID19-PoC SLT16_04; NCT04885478).