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Arrhythmia prophylaxis after aorta-coronary bypass

1985; Elsevier BV; Volume: 89; Issue: 3 Linguagem: Inglês

10.1016/s0022-5223(19)38793-8

1097-685X

M. Matangi, John M. Neutze, Kenneth J. Graham, David Hill, Alan Kerr, Brian G. Barratt‐Boyes,

Cardiac Arrhythmias and Treatments

After aorta-coronary bypass grafting, 164 consecutive patients were randomized to receive propranolol 5 mg every 6 hours orally (n = 82) or to serve as control subjects (n = 82). All patients were receiving beta blockers preoperatively. There were no significant differences between the two groups. The incidence of sustained supraventricular (nonsinus) tachyarrhythmias was 23% in the control group and 9.8% in the treated group (p = 0.02). The incidence of ventricular arrhythmias was 15% in the control group and 2.4% in the treated group (p = 0.005). The overall difference in clincially important arrhythmias was 38% in the control group and 12.2% in the treated group (p = 0.0002). We conclude that low-dose oral propranolol in patients who were receiving beta blockers preoperatively is effective in reducing the incidence of clinically important arrhythmias occurring after aorta-coronary bypass grafting.