Evaluation of Functional Nerve Recovery after Reconstruction with a New Biodegradable Poly (DL-Lactide-∊-Caprolactone) Nerve Guide
1997; SAGE Publishing; Volume: 20; Issue: 8 Linguagem: Inglês
10.1177/039139889702000809
ISSN1724-6040
AutoresMarcel F. Meek, Wilfred F.A. den Dunnen, P. H. Robinson, A. J. Pennings, J. M. Schakenraad,
Tópico(s)Pain Mechanisms and Treatments
ResumoThe aim of this study was to evaluate functional nerve recovery following reconstruction of a 1 cm gap in the sciatic nerve of a rat, using a new biodegradable p (DLLA-∊-CL) nerve guide. To evaluate both motor and sensory nerve recovery, walking track analysis and electrostimulation tests were carried out after implantation periods, ranging from 3 to 15 weeks post-operatively. The first signs of functional nerve recovery were observed after 3 weeks. After 15 weeks, 70% of the motor - and 90% of the sensory nerve function was re-established. Return of nerve function was better, in comparison with results from other studies. This study demonstrated successful functional nerve recovery after the reconstruction of a 1 cm nerve gap with a biodegradable p(DLLA-∊-CL) nerve guide.
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