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Prior aerobic physical training modulates neuropeptide expression and central thermoregulation after ovariectomy in the rat

2022; Elsevier BV; Volume: 558; Linguagem: Inglês

10.1016/j.mce.2022.111756

1872-8057

Talita Emanuela Domingues, Caíque Olegário Diniz e Magalhães, Raphael E. Szawka, Adelina M. Reis, Patrícia Costa Henriques, Kaoma Stephani da Costa Silva, Sabrina Paula Costa, Sara Barros Silva, Sueli Ferreira da Fonseca, Cíntia Maria Rodrigues, Marco Fabrício Dias‐Peixoto, Cândido Celso Coimbra, Vanessa Amaral Mendonça, Pedro Henrique Figueiredo Scheidet, Kinulpe Honorato‐Sampaio, Ana Cristina Rodrigues Lacerda,

Ovarian function and disorders

This study compared the effects of aerobic physical training and estradiol (E2) replacement on central pathways involved with thermoregulation in ovariectomized rats. Rats were assigned to untrained ovariectomized treated with placebo (UN-OVX), untrained ovariectomized treated with E2 (E2-OVX), and trained ovariectomized (TR-OVX) groups. Tail skin temperature (TST), internal temperature (Tint), and basal oxygen consumption (VO2) were recorded. Neuronal activity, brain expression of Kiss1, NKB and Prodyn, and central norepinephrine (NE) levels were measured. UN-OVX had the highest TST. Compared to UN-OVX rats, TR-OVX and E2-OVX had lower Fos expression in the paraventricular and arcuate (ARC) nuclei, and lower double labeling for Tyrosine Hydroxylase and Fos in the brainstem. Compared to UN-OVX, only TR-OVX group exhibited lower kisspeptin (Kiss1), neurokinin B (NKB), and prodynorphin expression in the ARC and higher central NE levels. Aerobic physical training before menopause may prevent the heat dissipation imbalance induced by reduction of E2, through central NE release, modulation of Kiss1, NKB and prodynorphin expression in neurons from ARC nucleus.