Produção Nacional
Revisado por pares
Intestinal Barrier Permeability in Obese Individuals with or without Metabolic Syndrome: A Systematic Review
2022; Multidisciplinary Digital Publishing Institute; Volume: 14; Issue: 17 Linguagem: Inglês
10.3390/nu14173649
ISSN2072-6643
AutoresMariana Duarte Bona, Carlos Henrique de Medeiros Torres, Severina Carla Vieira Cunha Lima, Ana Heloneida de Araújo Morais, Aldo Â. M. Lima, Bruna Leal Lima Maciel,
Tópico(s)Barrier Structure and Function Studies
ResumoAltered intestinal barrier permeability has been associated with obesity and its metabolic and inflammatory complications in animal models. The purpose of this systematic review is to assess the evidence regarding the association between obesity with or without Metabolic Syndrome (MetS) and alteration of the intestinal barrier permeability in humans. A systematic search of the studies published up until April 2022 in Latin America & Caribbean Health Sciences Literature (LILACS), PubMed, Scopus, Embase, and ScienceDirect databases was conducted. The methodological quality of the studies was assessed using the Newcastle-Ottawa scale (NOS) and the Agency for Healthcare Research and Quality (AHRQ) checklist. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework was used to assess the quality of the evidence. Eight studies were included and classified as moderate to high quality. Alteration of intestinal barrier permeability was evaluated by zonulin, lactulose/mannitol, sucralose, sucrose, lactulose/L-rhamnose, and sucralose/erythritol. Impaired intestinal barrier permeability measured by serum and plasma zonulin concentration was positively associated with obesity with MetS. Nonetheless, the GRADE assessment indicated a very low to low level of evidence for the outcomes. Thus, clear evidence about the relationship between alteration of human intestinal barrier permeability, obesity, and MetS was not found.
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