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Heritable cancer predisposition testing in pediatric cancer patients excluding retinoblastoma in a middle‐income country

2022; Wiley; Volume: 69; Issue: 11 Linguagem: Inglês

10.1002/pbc.29982

1545-5017

Omar El Khatib, Yasser Yahya, Rami Mahfouz, Lama Hamadeh, Maya Basbous, Miguel R. Abboud, Samar Muwakkit, Carlos Rodríguez‐Galindo, Sima Jeha, Raya Saab,

Ocular Oncology and Treatments

Resource-limited settings often have financial barriers to genetic testing for heritable cancer. This retrospective study investigated the pattern of heritable cancer predisposition testing in a middle-income country over the period 2014-2021, excluding retinoblastoma. After establishing a specific fund in 2019, rate of tests increased from 1.1% to 10.9% of new diagnoses. Most common testing was for constitutional mismatch repair deficiency (CMMRD), rhabdoid predisposition syndrome, TP53 (tumor protein 53) mutation, and hereditary cancer panel. Of 33 patients, 13 (39%) tested positive, 12 (36%) negative, and eight (24%) had variants of unknown significance. Positivity rate was 43% for a clinical phenotype and 44% for a tumor type indication.