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Biomarkers for dementia in Latin American countries: Gaps and opportunities

2022; Wiley; Volume: 19; Issue: 2 Linguagem: Inglês

10.1002/alz.12757

1552-5279

Mario A. Parra, Paulina Orellana, Tomás León, Victoria Cabello, Fernando Henríquez, Rodrigo Gómez, Constanza Avalos, Andrés Damián, Andrea Slachevsky, Agustín Ibáñez, Henrik Zetterberg, Betty M. Tijms, Jennifer S. Yokoyama, Stefanie Danielle Piña‐Escudero, J. Nicholas Cochran, Diana Matallana, Daisy Acosta, Ricardo Allegri, Bianca P. Arias‐Suárez, Bernardo Barra, María Isabel Behrens, Sônia Maria Dozzi Brucki, Geraldo F. Busatto, Paulo Caramelli, Sheila Castro‐Suárez, Valeria Contreras, Nilton Custodio, Sergio Dansilio, Myriam De la Cruz‐Puebla, Leonardo Cruz de Souza, Monica M. Diaz, Lissette Duque, Gonzalo Farías, Sérgio T. Ferreira, Nahuel Magrath Guimet, Ana Kmaid, David Lira, Francisco Lopera, Beatriz Mar Meza, Eliane Correa Miotto, Ricardo Nitríni, Alberto Núñez, Santiago O’Neill, John Fredy Ochoa, Maritza Pintado‐Caipa, Elisa de Paula França Resende, Shannon L. Risacher, Luz Ángela Rojas Bernal, Valentina Sabaj, Lucas Porcello Schilling, Allis F. Sellek, Ana Luisa Sosa, Leonel Tadao Takada, Antônio Lúcio Teixeira, Martha Unaucho‐Pilalumbo, Claudia Durán-Aniotz,

S100 Proteins and Annexins

Abstract Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we reported a survey to explore the ongoing work, needs, interests, potential barriers, and opportunities for future studies related to biomarkers. The results show that neuroimaging is the most used biomarker (73%), followed by genetic studies (40%), peripheral fluids biomarkers (31%), and cerebrospinal fluid biomarkers (29%). Regarding barriers in LAC, lack of funding appears to undermine the implementation of biomarkers in clinical or research settings, followed by insufficient infrastructure and training. The survey revealed that despite the above barriers, the region holds a great potential to advance dementia biomarkers research. Considering the unique contributions that LAC could make to this growing field, we highlight the urgent need to expand biomarker research. These insights allowed us to propose an action plan that addresses the recommendations for a biomarker framework recently proposed by regional experts.