Epstein-Barr virus: Biology and clinical disease
2022; Cell Press; Volume: 185; Issue: 20 Linguagem: Inglês
10.1016/j.cell.2022.08.026
ISSN1097-4172
AutoresBlossom Damania, Shannon C. Kenney, Nancy Raab‐Traub,
Tópico(s)Eosinophilic Disorders and Syndromes
ResumoEpstein-Barr virus (EBV) is a ubiquitous, oncogenic virus that is associated with a number of different human malignancies as well as autoimmune disorders. The expression of EBV viral proteins and non-coding RNAs contribute to EBV-mediated disease pathologies. The virus establishes life-long latency in the human host and is adept at evading host innate and adaptive immune responses. In this review, we discuss the life cycle of EBV, the various functions of EBV-encoded proteins and RNAs, the ability of the virus to activate and evade immune responses, as well as the neoplastic and autoimmune diseases that are associated with EBV infection in the human population.
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