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Lifestyle and NR3C1 exon 1F gene methylation is associated with changes in glucose levels and insulin resistance

2022; Elsevier BV; Volume: 309; Linguagem: Inglês

10.1016/j.lfs.2022.120940

1879-0631

Marcele Lorentz Mattos de Souza, Aline Ribeiro Borçoi, Bruna Aparecida Borges Dutra, Tamires dos Santos Vieira, Suzanny Oliveira Mendes, Ivana Alece Arantes Moreno, Bárbara Risse Quaioto, Amanda Sgrancio Olinda, Ester Ribeiro Cunha, Flávia Vitorino Freitas, Júlia Assis Pinheiro, Joaquim Gasparini dos Santos, Bruna Pereira Sorroche, Lídia Maria Rebolho Batista Arantes, Carmem Luíza Sartório, Adriana Madeira Alvares da Silva,

Childhood Cancer Survivors' Quality of Life

the present study aimed to investigate how glucose and insulin levels may be associated with changes in NR3C1 gene methylation levels in adults.375 volunteers users of the Brazilian Public Unified Health System (SUS) were recruited to assess socioeconomic status, lifestyle, anthropometric data, blood glucose and serum cortisol levels, insulin resistance, and NR3C1 gene methylation assessment. Factors associated with glucose levels and insulin resistance were investigated using multivariate analysis GLzM at 5% significance (p<0.05).our results verified that glucose levels and insulin resistance were directly related to NR3C1 gene methylation and age, while not being overweight and obese and no tobacco consumption were indirectly related to glucose levels and insulin resistance.habits and lifestyle may influence NR3C1 gene regulation, revealing the complexity of environmental impacts on NR3C1 methylation. Furthermore, associated risk factors must be taken into account in epigenetic studies as they directly interfere with blood glucose levels and insulin resistance.