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Immunologic Diagnosis of Endemic Mycoses

2022; Multidisciplinary Digital Publishing Institute; Volume: 8; Issue: 10 Linguagem: Inglês

10.3390/jof8100993

2309-608X

Rodrigo Almeida‐Paes, Andréa Reis Bernardes‐Engemann, Beatriz da Silva Motta, Cláudia Vera Pizzini, Marcos de Abreu Almeida, Mauro de Medeiros Muniz, Renata Alves Barcelos Dias, Rosely Maria Zancopé‐Oliveira,

Infectious Diseases and Mycology

The endemic mycoses blastomycosis, coccidioidomycosis, histoplasmosis, paracoccidioidomycosis, cryptococcosis, sporotrichosis, talaromycosis, adiaspiromycosis, and emergomycosis are mostly caused by geographically limited thermally dimorphic fungi (except for cryptococcosis), and their diagnoses can be challenging. Usual laboratory methods involved in endemic mycoses diagnosis include microscopic examination and culture of biological samples; however, serologic, histopathologic, and molecular techniques have been implemented in the last few years for the diagnosis of these mycoses since the recovery and identification of their etiologic agents is time-consuming and lacks in sensitivity. In this review, we focus on the immunologic diagnostic methods related to antibody and antigen detection since their evidence is presumptive diagnosis, and in some mycoses, such as cryptococcosis, it is definitive diagnosis.