Synthesis of Ribosomally Synthesized and Post-Translationally Modified Peptides Containing C–C Cross-Links
2022; American Chemical Society; Volume: 85; Issue: 10 Linguagem: Inglês
10.1021/acs.jnatprod.2c00508
ISSN1520-6025
AutoresDavid Laws, Eleda V. Plouch, Simon B. Blakey,
Tópico(s)Synthetic Organic Chemistry Methods
ResumoRibosomally synthesized and post-translationally modified peptides (RiPPs) are known for their macrocyclic structures, which impart unique biological activity. One rapidly emerging subclass of RiPP natural products contains macrocyclic C–C cross-links between two amino acid side chains. These linkages, often biosynthetically formed by a single rSAM or P450 enzyme, introduce significant structural and synthetic complexity to the molecules. While nature utilizes elegant mechanisms to produce C–C cross-linked RiPPs, synthetic tools are only able to access a portion of these biologically relevant natural products. This review provides an overview of the structures in this subclass as well as a discussion on their chemical syntheses.
Referência(s)